Intratracheal aerosolization of viral vectors to newborn pig airways

Gene therapy for airway diseases requires efficient delivery of nucleic acids to the airways. In small animal models, gene delivery reagents are commonly delivered as a bolus dose. However, large animal models are often more relevant for the transition from preclinical studies to human trials. Aeros...

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Bibliographische Detailangaben
Veröffentlicht in:BioTechniques. - 1991. - 68(2020), 5 vom: 01. Mai, Seite 235-239
1. Verfasser: Cooney, Ashley L (VerfasserIn)
Weitere Verfasser: Sinn, Patrick L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:BioTechniques
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't gene therapy gene transfer intubation microsprayer porcine viral vector delivery Aerosols