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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.0c00198
|2 doi
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|a pubmed24n1352.xml
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|a (NLM)32131599
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|a DE-627
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|a eng
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| 100 |
1 |
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|a Pelin, Juliane N B D
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Amyloid Peptide Mixtures
|b Self-Assembly, Hydrogelation, Nematic Ordering, and Catalysts in Aldol Reactions
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 30.07.2020
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|a Date Revised 28.03.2024
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Morphological, spectroscopic, and scattering studies of the self-assembly and aggregation of mixtures of [RF]4 and P[RF]4 peptides (where R = arginine; F = phenylalanine; P = proline), in solution and as hydrogels, were performed to obtain information about polymorphism. CD data confirmed a β-sheet secondary structure in aqueous solution, and TEM images revealed nanofibers with diameters of ∼10 nm and micrometer lengths. SAXS curves were fitted using a mass fractal-component and a long cylinder shell form factor for the liquid samples, and only a long cylinder shell form factor for the gels. Increasing the P[RF]4 content in the systems leads to a reduction in cylinder radius and core scattering density, suggesting an increase in packing of the peptide molecules; however, the opposite effect is observed for the gels, where the scattering density is higher in the shell for the systems containing higher P[RF]4 content. These compounds show potential as catalysts in the asymmetric aldol reactions, with cyclohexanone and p-nitrobenzaldehyde in aqueous media. A moderate conversion (36.9%) and a good stereoselectivity (69:31) were observed for the system containing only [RF]4. With increasing P[RF]4 content, a considerable decrease of the conversion was observed, suggesting differences in the self-assembly and packing factor. Rheological measurements were performed to determine the shear moduli for the soft gels
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Gerbelli, Barbara B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Edwards-Gayle, Charlotte J C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Aguilar, Andrea M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Castelletto, Valeria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hamley, Ian W
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Alves, Wendel A
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 36(2020), 11 vom: 24. März, Seite 2767-2774
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:36
|g year:2020
|g number:11
|g day:24
|g month:03
|g pages:2767-2774
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|u http://dx.doi.org/10.1021/acs.langmuir.0c00198
|3 Volltext
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