A cell-based assay for the detection of neutralizing antibodies against alemtuzumab

Aim: The humanized anti-CD52 monoclonal antibody alemtuzumab depletes lymphocytes and is currently used to treat relapsing multiple sclerosis. During treatment, anti-alemtuzumab antibodies may develop and reduce effective lymphocyte depletion in future treatment cycles. Results: Alemtuzumab-Alexa Fl...

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Publié dans:	BioTechniques. - 1993. - 68(2020), 4 vom: 06. Apr., Seite 185-190
Auteur principal:	Ali, Liaqat (Auteur)
Autres auteurs:	Saxena, Gauri, Jones, Meleri, Leisegang, Georgia R, Gammon, Luke, Gnanapavan, Sharmilee, Giovannoni, Gavin, Schmierer, Klaus, Baker, David, Kang, Angray S
Format:	Article en ligne
Langue:	English
Publié:	2020
Accès à la collection:	BioTechniques
Sujets:	Journal Article Research Support, Non-U.S. Gov't alemtuzumab antidrug antibodies multiple sclerosis neutralizing antibodies Antibodies, Neutralizing CD52 Antigen Fluoresceins Sulfonic Acids plus... alexa fluor 488 Alemtuzumab 3A189DH42V