Histone deacetylases inhibitor and RAD51 recombinase increase transcription activator-like effector nucleases-mediated homologous recombination on the bovine β-casein gene locus

OBJECTIVE: The efficiency of the knock-in process is very important to successful gene editing in domestic animals. Recently, it was reported that transient loosening of the nucleosomal folding of transcriptionally inactive chromatin might have the potential to enhance homologous recombination effic...

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Veröffentlicht in:	Asian-Australasian journal of animal sciences. - 1998. - 33(2020), 6 vom: 12. Juni, Seite 1023-1033
1. Verfasser:	Park, Da Som (VerfasserIn)
Weitere Verfasser:	Kim, Se Eun, Koo, Deog-Bon, Kang, Man-Jong
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2020
Zugriff auf das übergeordnete Werk:	Asian-Australasian journal of animal sciences
Schlagworte:	Journal Article Histone Deacetylases (HDAC) Inhibitor Homologous Recombination (HR) Knock-in RAD51 recombinase (RAD51) Transcription Activator-like Effector Nucleases (TALEN)