Mercury-induced autoimmunity : Drifting from micro to macro concerns on autoimmune disorders

Copyright © 2020 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 213(2020) vom: 30. Apr., Seite 108352
1. Verfasser: Bjørklund, Geir (VerfasserIn)
Weitere Verfasser: Peana, Massimiliano, Dadar, Maryam, Chirumbolo, Salvatore, Aaseth, Jan, Martins, Natália
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Review Acrodynia Allergy Autism Autoimmunity Chronic fatigue syndrome Delayed-type hypersensitivity Lupus Mercury mehr... Multiple sclerosis Neurodegenerative disease FXS1BY2PGL
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520 |a Mercury (Hg) is widely recognized as a neurotoxic metal, besides it can also act as a proinflammatory agent and immunostimulant, depending on individual exposure and susceptibility. Mercury exposure may arise from internal body pathways, such as via dental amalgams, preservatives in drugs and vaccines, and seafood consumption, or even from external pathways, i.e., occupational exposure, environmental pollution, and handling of metallic items and cosmetics containing Hg. In susceptible individuals, chronic low Hg exposure may trigger local and systemic inflammation, even exacerbating the already existing autoimmune response in patients with autoimmunity. Mercury exposure can trigger dysfunction of the autoimmune responses and aggravate immunotoxic effects associated with elevated serum autoantibodies titers. The purpose of the present review is to provide a critical overview of the many issues associated with Hg exposure and autoimmunity. In addition, the paper focuses on individual susceptibility and other health effects of Hg 
650 4 |a Journal Article 
650 4 |a Review 
650 4 |a Acrodynia 
650 4 |a Allergy 
650 4 |a Autism 
650 4 |a Autoimmunity 
650 4 |a Chronic fatigue syndrome 
650 4 |a Delayed-type hypersensitivity 
650 4 |a Lupus 
650 4 |a Mercury 
650 4 |a Multiple sclerosis 
650 4 |a Neurodegenerative disease 
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700 1 |a Peana, Massimiliano  |e verfasserin  |4 aut 
700 1 |a Dadar, Maryam  |e verfasserin  |4 aut 
700 1 |a Chirumbolo, Salvatore  |e verfasserin  |4 aut 
700 1 |a Aaseth, Jan  |e verfasserin  |4 aut 
700 1 |a Martins, Natália  |e verfasserin  |4 aut 
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