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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201907855
|2 doi
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|a pubmed24n1020.xml
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|a (DE-627)NLM306177358
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|a (NLM)32022978
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Xi, Dongmei
|e verfasserin
|4 aut
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| 245 |
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|a NIR Light-Driving Barrier-Free Group Rotation in Nanoparticles with an 88.3% Photothermal Conversion Efficiency for Photothermal Therapy
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 17.12.2020
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|a Date Revised 17.12.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Traditional photothermal therapy requires high-intensity laser excitation for cancer treatments due to the low photothermal conversion efficiency (PCE) of photothermal agents (PTAs). PTAs with ultra-high PCEs can decrease the required excited light intensity, which allows safe and efficient therapy in deep tissues. In this work, a PTA is synthesized with high PCE of 88.3% based on a BODIPY scaffold, by introducing a CF3 "barrier-free" rotor on the meso-position (tfm-BDP). In both the ground and excited state, the CF3 moiety in tfm-BDP has no energy barrier to rotation, allowing it to efficiently dissipate absorbed (NIR) photons as heat. Importantly, the barrier-free rotation of CF3 can be maintained after encapsulating tfm-BDP into polymeric nanoparticles (NPs). Thus, laser irradiation with safe intensity (0.3 W cm-2 , 808 nm) can lead to complete tumor ablation in tumor-bearing mice after intravenous injection of tfm-BDP NPs. This strategy of "barrier-free rotation" provides a new platform for future design of PTT agents for clinical cancer treatment
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|a Journal Article
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|a NIR light
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|a barrier-free rotation
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|a photothermal therapy
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|a polymeric nanoparticles
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|a safe intensity light
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|a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
|2 NLM
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|a Boron Compounds
|2 NLM
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|a Polymers
|2 NLM
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| 700 |
1 |
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|a Xiao, Ming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cao, Jianfang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Luyang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Ning
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Long, Saran
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fan, Jiangli
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shao, Kun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Wen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Xuehai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Peng, Xiaojun
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 32(2020), 11 vom: 16. März, Seite e1907855
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
1 |
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|g volume:32
|g year:2020
|g number:11
|g day:16
|g month:03
|g pages:e1907855
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| 856 |
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|u http://dx.doi.org/10.1002/adma.201907855
|3 Volltext
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