Altered Brain Structure and Functional Connectivity Associated with Pubertal Hormones in Girls with Precocious Puberty

Altered Brain Structure and Functional Connectivity Associated with Pubertal Hormones in Girls with Precocious Puberty

Copyright © 2019 Tao Chen et al.

Détails bibliographiques
Publié dans:Neural plasticity. - 1998. - 2019(2019) vom: 08., Seite 1465632
Auteur principal: Chen, Tao (Auteur)
Autres auteurs: Lu, Yi, Wang, Yu, Guo, Anna, Xie, Xiaoling, Fu, Yuchuan, Shen, Bangli, Lin, Wenxiao, Yang, Di, Zhou, Lu, Liu, Xiaozheng, Liu, Peining, Yan, Zhihan
Format: Article en ligne
Langue:English
Publié: 2019
Accès à la collection:Neural plasticity
Sujets:Journal Article Research Support, Non-U.S. Gov't Estradiol 4TI98Z838E Luteinizing Hormone 9002-67-9 Follicle Stimulating Hormone 9002-68-0
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520 |a Pubertal hormones play an important role in brain and psychosocial development. However, the role of abnormal HPG axis states in altering brain function and structure remains unclear. The present study is aimed at determining whether there were significant differences in gray matter volume (GMV) and resting state (RS) functional connectivity (FC) patterns in girls with idiopathic central precocious puberty (CPP) and peripheral precocious puberty (PPP). We further explored the correlation between these differences and serum pubertal hormone levels. To assess this, we recruited 29 idiopathic CPP girls and 38 age-matched PPP girls. A gonadotropin-releasing hormone (GnRH) stimulation test was performed, and pubertal hormone levels (including luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), prolactin, and cortisol) were assessed. All subjects underwent multimodal magnetic resonance imaging of brain structure and function. Voxel-based morphometry (VBM) analysis was paired with seed-to-voxel whole-brain RS-FC analysis to calculate the GMV and RS-FC in idiopathic CPP and PPP girls. Correlation analyses were used to assess the effects of pubertal hormones on brain regions with structural and functional differences between the groups. We found that girls with CPP exhibited decreased GMV in the left insula and left fusiform gyrus, while connectivity between the left and right insula and the right middle frontal gyrus (MFG), as well as the left fusiform gyrus and right amygdala, was reduced in girls with CPP. Furthermore, the GMV of the left insula and peak FSH levels were negatively correlated while higher basal and peak E2 levels were associated with increased bilateral insula RS-FC. These findings suggest that premature activation of the HPG axis and pubertal hormone fluctuations alter brain structure and function involved in the cognitive and emotional process in early childhood. These findings provide vital insights into the early pathophysiology of idiopathic CPP 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
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650 7 |a 4TI98Z838E  |2 NLM 
650 7 |a Luteinizing Hormone  |2 NLM 
650 7 |a 9002-67-9  |2 NLM 
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700 1 |a Lu, Yi  |e verfasserin  |4 aut 
700 1 |a Wang, Yu  |e verfasserin  |4 aut 
700 1 |a Guo, Anna  |e verfasserin  |4 aut 
700 1 |a Xie, Xiaoling  |e verfasserin  |4 aut 
700 1 |a Fu, Yuchuan  |e verfasserin  |4 aut 
700 1 |a Shen, Bangli  |e verfasserin  |4 aut 
700 1 |a Lin, Wenxiao  |e verfasserin  |4 aut 
700 1 |a Yang, Di  |e verfasserin  |4 aut 
700 1 |a Zhou, Lu  |e verfasserin  |4 aut 
700 1 |a Liu, Xiaozheng  |e verfasserin  |4 aut 
700 1 |a Liu, Peining  |e verfasserin  |4 aut 
700 1 |a Yan, Zhihan  |e verfasserin  |4 aut 
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