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20231225120853.0 |
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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2020.108343
|2 doi
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|a pubmed24n1017.xml
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|a (DE-627)NLM305297546
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|a (NLM)31931123
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|a (PII)S1521-6616(19)30385-7
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhang, Hui
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The increased IL-17-producing γδT cells promote tumor cell proliferation and migration in neuroblastoma
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| 264 |
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|c 2020
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 04.08.2020
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|a Date Revised 04.08.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2020 Elsevier Inc. All rights reserved.
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|a Neuroblastoma (NB) is the most common solid extracranial malignancy in children with a considerable chance of metastatic progression. Prevalent evidence supports the anti-tumor role of γδT cells and these cells have been testing in clinical trials for constraining tumor growth. A small subpopulation of γδT cells releasing IL-17, however, were demonstrated to exert tumor-promoting effects in many aspects. In this study, we found an augment of IL-17+ γδT cells both in in vitro PAM-stimulated γδT-cell expanding culture and circulating γδT cells in NB patients. These patient-origin cells expanded in vitro by PAM in the presence of IL-17 polarizing condition were shown to promote the proliferation and migration of NB cells. Furthermore, an intrinsic preference for IL-17 polarization in NB γδT cells was revealed by mRNA microarray and Western Blot, which pointed to an up-regulated expression of multiple Th17-development related genes in addition to an increased phosphorylation level of STAT3
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4 |
|a Journal Article
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a IL-17-producing γδT cells
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| 650 |
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4 |
|a Migration
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| 650 |
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4 |
|a Neuroblastoma
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| 650 |
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4 |
|a Proliferation
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| 650 |
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7 |
|a Interleukin-17
|2 NLM
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| 700 |
1 |
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|a Chai, Wenjia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yang, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Han, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mou, Wenjun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xi, Yue
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Qin, Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Huanmin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ma, Xiaoli
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Xiaolin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gui, Jingang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 211(2020) vom: 01. Feb., Seite 108343
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:211
|g year:2020
|g day:01
|g month:02
|g pages:108343
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2020.108343
|3 Volltext
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