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DE-627 |
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20231225120809.0 |
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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-019-02158-3
|2 doi
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|a pubmed24n1017.xml
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|a (NLM)31927676
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Galdiero, Emilia
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Quantum dots functionalized with gH625 attenuate QDs oxidative stress and lethality in Caenorhabditis elegans
|b a model system
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 25.03.2020
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Nanomaterials have revolutionized many scientific fields and are widely applied to address environmental problems and to develop novel health care strategies. However, their mechanism of action is still poorly understood. Several nanomaterials for medical applications are based on quantum dots (QDs). Despite their amazing physico-chemical properties, quantum dots display significant adverse effects. In the present study, the effects of QDs on the motor nervous system of nematodes Caenorhabditis elegans have been investigated as a non-mammalian alternative model. We also explored the possibility of modifying the toxicity of QDs by coating with a cell-penetrating peptide gH625 and thus we analysed the effects determined by QDs-gH625 complexes on the nematodes. With this work, we have demonstrated, by in vivo experiments, that the peptide gH625 is able to reduce the side effects of metallic nanoparticle making them more suitable for medical applications
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|a Journal Article
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|a Caenorhabditis elegans
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|a Drug delivery
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|a Ecotoxicity
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|a Quantum dots
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| 650 |
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|a Peptides
|2 NLM
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|a Viral Envelope Proteins
|2 NLM
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| 650 |
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|a gH625 peptide, Herpes simplex virus type I
|2 NLM
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1 |
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|a Siciliano, Antonietta
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lombardi, Lucia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Falanga, Annarita
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Galdiero, Stefania
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martucci, Francesca
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guida, Marco
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 29(2020), 2 vom: 11. März, Seite 156-162
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
1 |
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|g volume:29
|g year:2020
|g number:2
|g day:11
|g month:03
|g pages:156-162
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|u http://dx.doi.org/10.1007/s10646-019-02158-3
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