Predictive value of mesangial C3 and C4d deposition in IgA nephropathy

Predictive value of mesangial C3 and C4d deposition in IgA nephropathy

Copyright © 2020 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 211(2020) vom: 25. Feb., Seite 108331
1. Verfasser: Nam, Ki Heon (VerfasserIn)
Weitere Verfasser: Joo, Young Su, Lee, Changhyun, Lee, Sangmi, Kim, Joohwan, Yun, Hae-Ryong, Park, Jung Tak, Chang, Tae Ik, Ryu, Dong-Ryeol, Yoo, Tae-Hyun, Chin, Ho Jun, Kang, Shin-Wook, Jeong, Hyeon Joo, Lim, Beom Jin, Han, Seung Hyeok, Korean GlomeruloNEphritis sTudy (KoGNET) Group
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't C3 C4d Complement IgA nephropathy C3 protein, human Complement C3 Complement C4
Beschreibung
Zusammenfassung:Copyright © 2020 Elsevier Inc. All rights reserved.
We aimed to determine the relative contribution of each complement (C3 and C4d) deposition to the progression of IgA nephropathy (IgAN). We enrolled a total of 380 patients with biopsy-confirmed IgAN. Mesangial deposition of C3(<2+ vs. ≥2+) and C4d(positive vs. negative) was evaluated by immunofluorescence staining and immunohistochemistry, respectively. Study endpoint was the composite of a 30% decline in eGFR or ESRD. The risk of reaching the primary outcome was significantly higher in patients having C3 ≥ 2+ and C4d(+) than in corresponding counterparts. Adding C3 deposition to clinical data acquired at kidney biopsy modestly increased the area under the receiver-operating characteristic curve, net reclassification improvement, and integrated discrimination improvement (IDI); adding C4d increased IDI only. In conclusion, mesangial C3 and C4d deposition was an independent risk factor for progression of IgAN. C3 showed better predictability than C4d, suggesting that lectin pathway alone has limited clinical prognostic value
Beschreibung:Date Completed 04.08.2020
Date Revised 04.08.2020
published: Print-Electronic
ErratumIn: Clin Immunol. 2020 Apr;213:108386. doi: 10.1016/j.clim.2020.108386. - PMID 32209314
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2019.108331