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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2019.108324
|2 doi
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|a pubmed24n1014.xml
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|a (DE-627)NLM304445363
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|a (NLM)31843567
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|a (PII)S1521-6616(19)30438-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Besteman, Sjanna B
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Signal inhibitory receptor on leukocytes (SIRL)-1 and leukocyte- associated immunoglobulin-like receptor (LAIR)-1 regulate neutrophil function in infants
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|c 2020
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 04.08.2020
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|a Date Revised 12.02.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2019 Elsevier Inc. All rights reserved.
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|a During severe respiratory syncytial virus (RSV) bronchiolitis there is a massive influx of activated neutrophils to the lungs. An exaggerated immune response contributes to lung damage and disease severity during RSV infection. We have previously shown that normal adult neutrophil function can be modulated by agonists of SIRL-1. Here we aimed to measure the potential of two immune checkpoints: SIRL-1 and LAIR-1, to regulate the function of fresh blood and sputum neutrophils from infants with and without severe RSV bronchiolitis. We show a modest inhibition of the oxidative burst through SIRL-1 and LAIR-1, in control and RSV-infected infants. In addition, SIRL-1 and LAIR-1 inhibited neutrophil extracellular traps (NET) formation by sputum neutrophils of RSV patients. Altogether our data show that inhibitory receptors LAIR-1 and SIRL-1 can be used to regulate neutrophil function
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Immune checkpoint
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| 650 |
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4 |
|a Neutrophil
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| 650 |
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4 |
|a Neutrophil extracellular traps
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| 650 |
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4 |
|a Oxidative burst
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| 650 |
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4 |
|a Respiratory syncytial virus
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| 650 |
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7 |
|a Receptors, Immunologic
|2 NLM
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| 650 |
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7 |
|a VSTM1 protein, human
|2 NLM
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| 650 |
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7 |
|a leukocyte-associated immunoglobulin-like receptor 1
|2 NLM
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| 700 |
1 |
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|a Callaghan, Amie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hennus, Marije P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Westerlaken, Geertje H A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meyaard, Linde
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bont, Louis L
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 211(2020) vom: 15. Feb., Seite 108324
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:211
|g year:2020
|g day:15
|g month:02
|g pages:108324
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2019.108324
|3 Volltext
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|a AR
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|d 211
|j 2020
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|h 108324
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