Discovery and Characterization of Halogenated Xanthene Inhibitors of DUSP5 as Potential Photodynamic Therapeutics
Dual specific phosphatases (DUSPs) are an important class of mitogen-activated protein kinase (MAPK) regulators, and are drug targets for treating vascular diseases. Previously we had shown that DUSP5 plays a role in embryonic vertebrate vascular patterning. Herein, we screened a library of FDA-appr...
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| Veröffentlicht in: | Journal of photochemistry and photobiology. A, Chemistry. - 1998. - 375(2019) vom: 15. Apr., Seite 114-131
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| 1. Verfasser: |
Bongard, Robert D
(VerfasserIn) |
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| Weitere Verfasser: |
Lepley, Michael,
Gastonguay, Adam,
Syrlybaeva, Raulia R,
Talipov, Marat R,
Lipinsky, Rachel A Jones,
Leigh, Noah R,
Brahmbhatt, Jaladhi,
Kutty, Raman,
Rathore, Rajendra,
Ramchandran, Ramani,
Sem, Daniel S |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2019
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| Zugriff auf das übergeordnete Werk: | Journal of photochemistry and photobiology. A, Chemistry
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| Schlagworte: | Journal Article
DUSP5
enzyme kinetics
eosin Y
merbromin
pERK
rose bengal
xanthene dyes |
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