Chronic lymphopenia and neutropenia in a dog with large granular lymphocytic leukemia
© 2019 American Society for Veterinary Clinical Pathology.
| Veröffentlicht in: | Veterinary clinical pathology. - 1975. - 48(2019), 4 vom: 15. Dez., Seite 721-724 |
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| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2019
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| Zugriff auf das übergeordnete Werk: | Veterinary clinical pathology |
| Schlagworte: | Case Reports Journal Article T-cell LGLL aleukemic leukemia chronic lymphocytic leukemia large granular lymphocytes molecular clonality testing subleukemic leukemia Anti-Bacterial Agents Prednisolone mehr... |
| Zusammenfassung: | © 2019 American Society for Veterinary Clinical Pathology. T-cell large granular lymphocytic leukemia (T-cell LGLL) is the most common presentation of chronic lymphocytic leukemia (CLL) in dogs. Aleukemic or subleukemic leukemia is a particularly rare variation in both humans and dogs, where bone marrow proliferation is either not or only sparsely translated in the peripheral blood. Neutropenia is a prominent feature in cases of human T-cell LGLL but is normally absent in canine CLL. This report describes a case of a dog presented with an almost 3-year history of asymptomatic neutropenia, lymphopenia, and thrombocytopenia (without anemia). A bone marrow examination, the exclusion of infectious diseases, and clonality testing led to the diagnosis of subleukemic LGLL that responded well to therapy (death occurred 2.5 years later due to an unrelated cause) |
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| Beschreibung: | Date Completed 02.06.2020 Date Revised 02.06.2020 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1939-165X |
| DOI: | 10.1111/vcp.12809 |