A Bioinspired Nanoprobe with Multilevel Responsive T1 -Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases

A Bioinspired Nanoprobe with Multilevel Responsive T1 -Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Détails bibliographiques
Publié dans:Advanced materials (Deerfield Beach, Fla.). - 1998. - 32(2020), 4 vom: 20. Jan., Seite e1906799
Auteur principal: Li, Yao (Auteur)
Autres auteurs: Zhao, Xiao, Liu, Xiaoli, Cheng, Keman, Han, Xuexiang, Zhang, Yinlong, Min, Huan, Liu, Guangna, Xu, Junchao, Shi, Jian, Qin, Hao, Fan, Haiming, Ren, Lei, Nie, Guangjun
Format: Article en ligne
Langue:English
Publié: 2020
Accès à la collection:Advanced materials (Deerfield Beach, Fla.)
Sujets:Journal Article T1-weighted detection magnetic resonance imaging (MRI) metastases signal-amplification ultrasmall manganese ferrite nanoparticles Contrast Media Ferric Compounds Fibronectins Manganese Compounds plus... Oligopeptides cysteinyl-arginyl-glutamyl-lysyl-alanyl manganese ferrite Fibrin 9001-31-4 Hydrogen Peroxide BBX060AN9V
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520 |a Metastasis remains the major cause of death in cancer patients. Thus, there is a need to sensitively detect tumor metastasis, especially ultrasmall metastasis, for early diagnosis and precise treatment of cancer. Herein, an ultrasensitive T1 -weighted magnetic resonance imaging (MRI) contrast agent, UMFNP-CREKA is reported. By conjugating the ultrasmall manganese ferrite nanoparticles (UMFNPs) with a tumor-targeting penta-peptide CREKA (Cys-Arg-Glu-Lys-Ala), ultrasmall breast cancer metastases are accurately detected. With a behavior similar to neutrophils' immunosurveillance process for eliminating foreign pathogens, UMFNP-CREKA exhibits a chemotactic "targeting-activation" capacity. UMFNP-CREKA is recruited to the margin of tumor metastases by the binding of CREKA with fibrin-fibronectin complexes, which are abundant around tumors, and then release of manganese ions (Mn2+ ) to the metastasis in response to pathological parameters (mild acidity and elevated H2 O2 ). The localized release of Mn2+ and its interaction with proteins affects a marked amplification of T1 -weighted magnetic resonance (MR) signals. In vivo T1 -weighted MRI experiments reveal that UMFNP-CREKA can detect metastases at an unprecedented minimum detection limit of 0.39 mm, which has significantly extended the detection limit of previously reported MRI probe 
650 4 |a Journal Article 
650 4 |a T1-weighted detection 
650 4 |a magnetic resonance imaging (MRI) 
650 4 |a metastases 
650 4 |a signal-amplification 
650 4 |a ultrasmall manganese ferrite nanoparticles 
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650 7 |a Ferric Compounds  |2 NLM 
650 7 |a Fibronectins  |2 NLM 
650 7 |a Manganese Compounds  |2 NLM 
650 7 |a Oligopeptides  |2 NLM 
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700 1 |a Zhao, Xiao  |e verfasserin  |4 aut 
700 1 |a Liu, Xiaoli  |e verfasserin  |4 aut 
700 1 |a Cheng, Keman  |e verfasserin  |4 aut 
700 1 |a Han, Xuexiang  |e verfasserin  |4 aut 
700 1 |a Zhang, Yinlong  |e verfasserin  |4 aut 
700 1 |a Min, Huan  |e verfasserin  |4 aut 
700 1 |a Liu, Guangna  |e verfasserin  |4 aut 
700 1 |a Xu, Junchao  |e verfasserin  |4 aut 
700 1 |a Shi, Jian  |e verfasserin  |4 aut 
700 1 |a Qin, Hao  |e verfasserin  |4 aut 
700 1 |a Fan, Haiming  |e verfasserin  |4 aut 
700 1 |a Ren, Lei  |e verfasserin  |4 aut 
700 1 |a Nie, Guangjun  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Advanced materials (Deerfield Beach, Fla.)  |d 1998  |g 32(2020), 4 vom: 20. Jan., Seite e1906799  |w (DE-627)NLM098206397  |x 1521-4095  |7 nnas 
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