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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2019.108314
|2 doi
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|a pubmed24n1012.xml
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|a (DE-627)NLM303682264
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|a (NLM)31765834
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|a (PII)S1521-6616(19)30597-2
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Arvaniti, Pinelopi
|e verfasserin
|4 aut
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| 245 |
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|a Linking genetic variation with epigenetic profiles in Sjögren's syndrome
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|c 2020
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 31.07.2020
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|a Date Revised 31.07.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.
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|a DNA methylation represents an important regulatory event governing gene expression that is dysregulated in Sjögren's syndrome (SjS) and a number of autoimmune/inflammatory diseases. As disease-associated single-nucleotide polymorphisms (SNPs) have relevance in controlling DNA methylation, 94 non-HLA SjS-SNPs were investigated, among them 57 (60.6%) with widespread effects on 197 individual DNA methylation quantitative trait loci (meQTL) were selected. Typically, these SNPs are intronic, possess an active promoter histone mark, and control cis-meQTLs located around transcription start sites. Interplay is independent of the physical distance between SNPs and meQTLs. Using epigenome-wide association study datasets, SjS-meQTLs were characterized (41 genes and 13 DNA methylation CpG motifs) and for the most part map to a pro-inflammatory cytokine pathway, which is important for the control of DNA methylation in autoimmune diseases. In conclusion, exploring meQTLs represents a valuable tool to predict and investigate downstream effects of genetic factors in complex diseases such as SjS
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Pro-inflammatory cytokine pathway
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|a SNP
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|a Sjögren's syndrome
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|a meQTL
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| 650 |
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|a Cytokines
|2 NLM
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| 700 |
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|a Le Dantec, Christelle
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Charras, Amandine
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Arleevskaya, Marina A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hedrich, Christian M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zachou, Kalliopi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dalekos, George N
|e verfasserin
|4 aut
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| 700 |
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|a Renaudineau, Yves
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 210(2020) vom: 01. Jan., Seite 108314
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|x 1521-7035
|7 nnns
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| 773 |
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|g volume:210
|g year:2020
|g day:01
|g month:01
|g pages:108314
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|u http://dx.doi.org/10.1016/j.clim.2019.108314
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