Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies

Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies

Copyright © 2019 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 210(2020) vom: 20. Jan., Seite 108307
1. Verfasser: Ochoa-Grullón, J (VerfasserIn)
Weitere Verfasser: Benavente Cuesta, C, Pérez López, C, Peña Cortijo, A, Rodríguez de la Peña, A, Álvarez Carmona, A, Mateo Morales, M, Llano-Hernández, K, Williams, L J, Rodríguez de Frías, E, Guevara-Hoyer, K, Cordero Torres, G, Orte, C, Fernández-Arquero, M, Fernández-Paredes, L, Serrano-García, I, Recio, M J, Pérez de Diego, R, Martínez, R, Sánchez-Ramón, S
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Observational Study Haematological malignancies Hypogammaglobulinemia Pneumo23 Specific polysaccharide ab response Typhim vi Antibodies, Bacterial Polysaccharides, Bacterial Typhoid-Paratyphoid Vaccines Vi polysaccharide vaccine, typhoid
Beschreibung
Zusammenfassung:Copyright © 2019 Elsevier Inc. All rights reserved.
An increasing healthcare challenge in the management of haematological malignancy (HM) is secondary immunodeficiency. From January 2019, the EMA included the evaluation of specific antibody (Ab) responses to better select patients for immunoglobulin replacement therapy (IgRT). We evaluated Ab responses to pneumococcal and Salmonella typhi pure polysaccharide immunization in a cohort of 42 HM patients and 24 healthy-controls. Pre-post specific Ab concentrations were measured by ELISA at 4 weeks. Globally, significantly lower Typhim Vi (TV) seroprevalence (9%) compared to 23-valent pneumococcal polysaccharide vaccine (PPV) (76%) (p <0.001) was observed. TV non responders (88%) were higher than PPV non responders (62%) (p <0.0001) and correlated better to infectious history. By ROC analysis, pre-post 5-fold TV increase was the best cut-off to discriminate HM with recurrent infections and controls (sensitivity 91%, specificity 100%). Despite the small sample cohort, our results suggest that specific anti-S typhi Ab response is a useful complementary assay in the diagnosis and management decision of SID to HM
Beschreibung:Date Completed 31.07.2020
Date Revised 31.07.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2019.108307