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231225s2020 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2019.108309
|2 doi
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|a pubmed24n1011.xml
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|a (DE-627)NLM303542438
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|a (NLM)31751612
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|a (PII)S1521-6616(19)30361-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a De Leo, Pasqualina
|e verfasserin
|4 aut
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| 245 |
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|a NFKB2 regulates human Tfh and Tfr pool formation and germinal center potential
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 31.07.2020
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|a Date Revised 31.07.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2019 Elsevier Inc. All rights reserved.
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|a Mutations affecting the non-canonical pathway of NF-κB were recently identified to underlie a form of common variable immunodeficiency strongly associated with autoimmunity. Although intrinsic B-cell abnormalities explain most of the humoral defects of this disease, detailed data on the impact of NFKB2 on follicular helper (Tfh) and regulatory (Tregs) T cells are scarce. Here, we show that Tfh, CXCR5+, and CXCR5- Treg cell subsets were significantly reduced in patients heterozygous for a truncating mutation of NFKB2. Plasma CXCL13 levels were reduced, underlining an important role for NFKB2 in regulating the germinal center (GC) response. Proinflammatory IFNγ, IL-17 and IL-10 cytokine production by CD4 T cells was lower in the mutated patients, but the production of IL-4 and IL-21 was not altered. Taken together, our findings show that NFKB2 influences the quality and efficiency of human GC reaction, by affecting not only the B cells but also GC-relevant T cell subsets
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Common variable immunodeficiency (CVID)
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|a Follicular helper T cells (Tfh)
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|a Follicular regulatory T cells (Tfr)
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|a NFKB2
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|a T regulatory cells (Treg)
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a NF-kappa B
|2 NLM
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| 650 |
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|a NF-kappa B p52 Subunit
|2 NLM
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| 650 |
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|a NFKB2 protein, human
|2 NLM
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| 700 |
1 |
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|a Gazzurelli, Luisa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Baronio, Manuela
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Montin, Davide
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Di Cesare, Silvia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Giancotta, Carmen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Licciardi, Francesco
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cancrini, Caterina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Aiuti, Alessandro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Plebani, Alessandro
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cicalese, Maria Pia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lougaris, Vassilios
|e verfasserin
|4 aut
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| 700 |
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|a Fousteri, Georgia
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 210(2020) vom: 01. Jan., Seite 108309
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:210
|g year:2020
|g day:01
|g month:01
|g pages:108309
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|u http://dx.doi.org/10.1016/j.clim.2019.108309
|3 Volltext
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|d 210
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|h 108309
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