|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM30306000X |
| 003 |
DE-627 |
| 005 |
20231225112032.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2019 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/acs.langmuir.9b02336
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1010.xml
|
| 035 |
|
|
|a (DE-627)NLM30306000X
|
| 035 |
|
|
|a (NLM)31702159
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Barriga, Hanna M G
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Engineering Swollen Cubosomes Using Cholesterol and Anionic Lipids
|
| 264 |
|
1 |
|c 2019
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 07.09.2020
|
| 500 |
|
|
|a Date Revised 07.09.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Dispersions of nonlamellar lipid membrane assemblies are gaining increasing interest for drug delivery and protein therapeutic application. A key bottleneck has been the lack of rational design rules for these systems linking different lipid species and conditions to defined lattice parameters and structures. We have developed robust methods to form cubosomes (nanoparticles with porous internal structures) with water channel diameters of up to 171 Å, which are over 4 times larger than archetypal cubosome structures. The water channel diameter can be tuned via the incorporation of cholesterol and the charged lipid DOPA, DOPG, or DOPS. We have found that large molecules can be incorporated into the porous cubosome structure and that these molecules can interact with the internal cubosome membrane. This offers huge potential for accessible encapsulation and protection of biomolecules and development of confined interfacial reaction environments
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Glycerophospholipids
|2 NLM
|
| 650 |
|
7 |
|a Cholesterol
|2 NLM
|
| 650 |
|
7 |
|a 97C5T2UQ7J
|2 NLM
|
| 700 |
1 |
|
|a Ces, Oscar
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Law, Robert V
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Seddon, John M
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Brooks, Nicholas J
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 50 vom: 17. Dez., Seite 16521-16527
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:35
|g year:2019
|g number:50
|g day:17
|g month:12
|g pages:16521-16527
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/acs.langmuir.9b02336
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 35
|j 2019
|e 50
|b 17
|c 12
|h 16521-16527
|