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|a 10.1016/j.clim.2019.108272
|2 doi
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|a eng
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| 100 |
1 |
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|a Song, Kangkang
|e verfasserin
|4 aut
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| 245 |
1 |
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|a An update on genetic susceptibility in lupus nephritis
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|c 2020
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 31.07.2020
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|a Date Revised 31.07.2020
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|a published: Print-Electronic
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|a ErratumIn: Clin Immunol. 2020 Jun;215:108389. - PMID 32245575
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2019. Published by Elsevier Inc.
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|a Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multiple system involvement and positive serum autoantibodies. Lupus nephritis (LN) is the most common and serious complication of SLE, and it is the main cause of death in patients with SLE. Abnormalities in the immune system lead to LN and involve a variety of cells (T cells, B cells, macrophages, NK cells, etc.), cytokines (interleukin, tumor necrosis factor α, etc.) and their related pathways. Previous studies have shown that the interactions of genetic, epigenetic and environmental factors contribute to the pathogenesis and development of LN. In recent years, one genome-wide association study (GWAS) and a number of gene association studies have explored the susceptibility genes of LN, including immunization-, inflammation-, adhesion- and other pathway-related genes. These genes participate in or suggest the pathogenesis and progression of LN. In this review, we summarize the genetic susceptibility of LN and discuss the possible mechanism underlying the susceptibility genes of LN
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Review
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| 650 |
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|a Genetics
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| 650 |
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|a Lupus nephritis
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| 650 |
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4 |
|a Susceptibility
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| 650 |
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4 |
|a Systemic lupus erythematosus
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| 700 |
1 |
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|a Liu, Lu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xuejun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xiangmei
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 210(2020) vom: 15. Jan., Seite 108272
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|g volume:210
|g year:2020
|g day:15
|g month:01
|g pages:108272
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|u http://dx.doi.org/10.1016/j.clim.2019.108272
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