Low Dose of X-Ray-Excited Long-Lasting Luminescent Concave Nanocubes in Highly Passive Targeting Deep-Seated Hepatic Tumors

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 31(2019), 49 vom: 16. Dez., Seite e1905087
1. Verfasser: Chen, Zheng-Zhe (VerfasserIn)
Weitere Verfasser: Wang, Liu-Chun, Manoharan, Divinah, Lee, Chin-Lai, Wu, Lai-Chin, Huang, Wan-Ting, Huang, Eng-Yen, Su, Chia-Hao, Sheu, Hwo-Shuenn, Yeh, Chen-Sheng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article X-rays ZnGa2O4:Cr cancer long-lasting luminescence passive targeting Luminescent Agents Chromium 0R0008Q3JB Zinc J41CSQ7QDS
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520 |a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 
520 |a Chromium-doped zinc gallate, ZnGa2 O4 :Cr3+ (ZGC), is viewed as a long-lasting luminescence (LLL) phosphor that can avoid tissue autofluorescence interference for in vivo imaging detection. ZGC is a cubic spinel structure, a typical agglomerative or clustered morphology lacking a defined cubic shape, but a sphere-like feature is commonly obtained for the nanometric ZGC. The substantial challenge remains achieving a well-defined cubic feature in nanoscale. The process by which dispersed and well-defined concave cubic ZGC is obtained is described, exhibiting much stronger LLL in UV and X-ray excitation for the dispersed cubic ZGC compared with the agglomerative form that cannot be excited using X-rays with a low dose of 0.5 Gy. The cubic ZGC reveals a specific accumulation in liver and 0.5 Gy used at the end of X-ray excitation is sufficient for imaging of deep-seated hepatic tumors. The ZGC nanocubes show highly passive targeting of orthotopic hepatic tumors 
650 4 |a Journal Article 
650 4 |a X-rays 
650 4 |a ZnGa2O4:Cr 
650 4 |a cancer 
650 4 |a long-lasting luminescence 
650 4 |a passive targeting 
650 7 |a Luminescent Agents  |2 NLM 
650 7 |a Chromium  |2 NLM 
650 7 |a 0R0008Q3JB  |2 NLM 
650 7 |a Zinc  |2 NLM 
650 7 |a J41CSQ7QDS  |2 NLM 
700 1 |a Wang, Liu-Chun  |e verfasserin  |4 aut 
700 1 |a Manoharan, Divinah  |e verfasserin  |4 aut 
700 1 |a Lee, Chin-Lai  |e verfasserin  |4 aut 
700 1 |a Wu, Lai-Chin  |e verfasserin  |4 aut 
700 1 |a Huang, Wan-Ting  |e verfasserin  |4 aut 
700 1 |a Huang, Eng-Yen  |e verfasserin  |4 aut 
700 1 |a Su, Chia-Hao  |e verfasserin  |4 aut 
700 1 |a Sheu, Hwo-Shuenn  |e verfasserin  |4 aut 
700 1 |a Yeh, Chen-Sheng  |e verfasserin  |4 aut 
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773 1 8 |g volume:31  |g year:2019  |g number:49  |g day:16  |g month:12  |g pages:e1905087 
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