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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201905761
|2 doi
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|a pubmed24n1007.xml
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|a (DE-627)NLM302319786
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|a (NLM)31625635
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Cui, Chunyan
|e verfasserin
|4 aut
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|a Water-Triggered Hyperbranched Polymer Universal Adhesives
|b From Strong Underwater Adhesion to Rapid Sealing Hemostasis
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 10.04.2020
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Despite recent advance in bioinspired adhesives, achieving strong adhesion and sealing hemostasis in aqueous and blood environments is challenging. A hyperbranched polymer (HBP) with a hydrophobic backbone and hydrophilic adhesive catechol side branches is designed and synthesized based on Michael addition reaction of multi-vinyl monomers with dopamine. It is demonstrated that upon contacting water, the hydrophobic chains self-aggregate to form coacervates quickly, displacing water molecules on the adherent surface to trigger increased exposure of catechol groups and thus rapidly strong adhesion to diverse materials from low surface energy to high energy in various environments, such as deionized water, sea water, PBS, and a wide range of pH solutions (pH = 3 to 11) without use of any oxidant. Also, this HBP adhesive (HBPA) exhibits a robust adhesion to fractured bone, precluding the problem of mismatched surface energy and mechanical properties. The HBPA's adhesion is repeatable in a wet condition. Intriguingly, the HBPA is capable of gluing dissimilar materials with distinct properties. Importantly, introducing long alkylamine into this modular hyperbranched architecture contributes to formation of an injectable hemostatic sealant that can rapidly stop visceral bleeding, especially hemorrhage from deep wound
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|a Journal Article
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|a adhesive
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|a coacervate
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|a hemostasis
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|a hyperbranched polymer
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|a underwater adhesion
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|a Adhesives
|2 NLM
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|a Biocompatible Materials
|2 NLM
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|a Catechols
|2 NLM
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|a Hemostatics
|2 NLM
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|a Polymers
|2 NLM
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|a Water
|2 NLM
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|a 059QF0KO0R
|2 NLM
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|a catechol
|2 NLM
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| 650 |
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|a LF3AJ089DQ
|2 NLM
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| 700 |
1 |
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|a Fan, Chuanchuan
|e verfasserin
|4 aut
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| 700 |
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|a Wu, Yuanhao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiao, Meng
|e verfasserin
|4 aut
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1 |
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|a Wu, Tengling
|e verfasserin
|4 aut
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1 |
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|a Zhang, Dongfei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Xinyu
|e verfasserin
|4 aut
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|a Liu, Bo
|e verfasserin
|4 aut
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|a Xu, Ziyang
|e verfasserin
|4 aut
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|a Qu, Bo
|e verfasserin
|4 aut
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| 700 |
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|a Liu, Wenguang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 49 vom: 16. Dez., Seite e1905761
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:31
|g year:2019
|g number:49
|g day:16
|g month:12
|g pages:e1905761
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|u http://dx.doi.org/10.1002/adma.201905761
|3 Volltext
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