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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.9b02487
|2 doi
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|a pubmed24n1006.xml
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|a (DE-627)NLM301997608
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|a (NLM)31592674
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|a DE-627
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|e rakwb
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|a eng
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|a Chirkov, N S
|e verfasserin
|4 aut
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|a Network Formation of DNA/Polyelectrolyte Fibrous Aggregates Adsorbed at the Water-Air Interface
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|c 2019
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|a Text
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|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 03.09.2020
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|a Date Revised 03.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a It is discovered that complexes of DNA and hydrophobically modified polyelectrolytes form a rigid network of threadlike or fibrous aggregates at the liquid-gas interface whose morphology can dramatically affect the mechanical properties. While mixed solutions of DNA and poly(N,N-diallyl-N,N-dimethylammonium chloride) (PDADMAC) exhibit no notable surface activity, the complexes formed from DNA with poly(N,N-diallyl-N-butyl-N-methylammonium chloride) are surface-active, in contrast to either of the separate components. Further, complexes of DNA and poly(N,N-diallyl-N-hexyl-N-methylammonium chloride) (PDAHMAC) with its longer hydrophobic side chains exhibit pronounced surface activity with values of surface pressures up to 16 mN/m and dynamic surface elasticity up to 58 mN/m. If the PDAHMAC nitrogen to DNA phosphate molar ratio, N/P, is between 0.6 and 3, abrupt compression of the adsorption layer leads unexpectedly to a noticeable decrease of the surface elasticity. The application of imaging techniques reveals that this effect is a consequence of the destruction of a rigid network of threadlike DNA/polyelectrolyte aggregates at the interface. The toroidal aggregates, which are typical for the bulk phase of DNA/PDADMAC solutions in this range of N/P ratios, are not observed in the surface layer. The observed link between the mechanical properties and interfacial morphology of surface-active complexes formed from DNA with hydrophobically modified polyelectrolytes indicates that tuning polyelectrolyte hydrophobicity in these systems may be a means to develop their use in applications ranging from nonviral gene-delivery vehicles to conductive nanowires
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Polyethylenes
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|a Quaternary Ammonium Compounds
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|a Water
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|a 059QF0KO0R
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|a poly-N,N-dimethyl-N,N-diallylammonium chloride
|2 NLM
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|a 26062-79-3
|2 NLM
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|a DNA
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|a 9007-49-2
|2 NLM
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|a Akentiev, A V
|e verfasserin
|4 aut
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|a Campbell, R A
|e verfasserin
|4 aut
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|a Lin, S-Y
|e verfasserin
|4 aut
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|a Timoshen, K A
|e verfasserin
|4 aut
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|a Vlasov, P S
|e verfasserin
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|a Noskov, B A
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 35(2019), 43 vom: 29. Okt., Seite 13967-13976
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:35
|g year:2019
|g number:43
|g day:29
|g month:10
|g pages:13967-13976
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|u http://dx.doi.org/10.1021/acs.langmuir.9b02487
|3 Volltext
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