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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.9b02275
|2 doi
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|a eng
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1 |
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|a Bernhard, Christoph
|e verfasserin
|4 aut
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| 245 |
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|a Both Poly(ethylene glycol) and Poly(methyl ethylene phosphate) Guide Oriented Adsorption of Specific Proteins
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|c 2019
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|a Text
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|a ƒaComputermedien
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|a Date Completed 03.09.2020
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|a Date Revised 03.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Developing new functional biomaterials requires the ability to simultaneously repel unwanted and guide wanted protein adsorption. Here, we systematically interrogate the factors determining the protein adsorption by comparing the behaviors of different polymeric surfaces, poly(ethylene glycol) and a poly(phosphoester), and five different natural proteins. Interestingly we observe that, at densities comparable to those used in nanocarrier functionalization, the same proteins are either adsorbed (fibrinogen, human serum albumin, and transferrin) or repelled (immunoglobulin G and lysozyme) by both polymers. However, when adsorption takes place, the specific surface dictates the amount and orientation of each protein
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Blood Proteins
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|a Polyethylene Glycols
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|a Roeters, Steven J
|e verfasserin
|4 aut
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1 |
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|a Bauer, Kristin N
|e verfasserin
|4 aut
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|a Weidner, Tobias
|e verfasserin
|4 aut
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|a Bonn, Mischa
|e verfasserin
|4 aut
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|a Wurm, Frederik R
|e verfasserin
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|a Gonella, Grazia
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 43 vom: 29. Okt., Seite 14092-14097
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|g year:2019
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|u http://dx.doi.org/10.1021/acs.langmuir.9b02275
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