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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.9b02549
|2 doi
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|a pubmed24n1005.xml
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|a (NLM)31568724
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Dong, Jia Jia
|e verfasserin
|4 aut
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| 245 |
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|a Contact Killing of Gram-Positive and Gram-Negative Bacteria on PDMS Provided with Immobilized Hyperbranched Antibacterial Coatings
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 03.09.2020
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|a Date Revised 03.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Here we describe in detail the preparation and application of antibacterial coatings on PDMS (poly(dimethylsiloxane)) and the contact-killing properties with 10 bacterial strains. Our aim was to develop a generally applicable coating to prevent biomaterial acquired infections, which is the major mode of failure of biomedical implants. In the first step, the surface was provided with a hydrophobic hyperbranched coating resin that was covalently attached to PDMS, mediated by an appropriate coupling agent. The coupling agent contained a siloxane group that reacts covalently with the silanol groups of air-plasma-treated PDMS and a blocked isocyanate enabling covalent coupling with the amino groups of the hyperbranched coating resins. The coating resins were functionalized with a polyethylenimine and subsequently quaternized with bromohexane and iodomethane. The coatings were highly effective against Gram-positive bacteria (five strains) and sufficiently active against Gram-negative bacteria (five stains). The killing effect on the latter group was strongly enhanced by adding a permeabilizer (EDTA). The biocidal efficacy was not influenced by the presence of (saliva) proteins
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Anti-Bacterial Agents
|2 NLM
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|a Coated Materials, Biocompatible
|2 NLM
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| 650 |
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|a Dimethylpolysiloxanes
|2 NLM
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|a baysilon
|2 NLM
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|a 63148-62-9
|2 NLM
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1 |
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|a Muszanska, Agnieszka
|e verfasserin
|4 aut
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1 |
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|a Xiang, Fei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Falkenberg, Richard
|e verfasserin
|4 aut
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|a van de Belt-Gritter, Betsy
|e verfasserin
|4 aut
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| 700 |
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|a Loontjens, Ton
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 43 vom: 29. Okt., Seite 14108-14116
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:35
|g year:2019
|g number:43
|g day:29
|g month:10
|g pages:14108-14116
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|u http://dx.doi.org/10.1021/acs.langmuir.9b02549
|3 Volltext
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