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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201904762
|2 doi
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|a pubmed24n1005.xml
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|e rakwb
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|a eng
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|a Zou, Jie
|e verfasserin
|4 aut
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|a Highly Efficient and Environmentally Friendly Fabrication of Robust, Programmable, and Biocompatible Anisotropic, All-Cellulose, Wrinkle-Patterned Hydrogels for Cell Alignment
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 30.03.2020
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Wrinkled hydrogels from biomass sources are potential structural biomaterials. However, for biorelated applications, engineering scalable, structure-customized, robust, and biocompatible wrinkled hydrogels with highly oriented nanostructures and controllable intervals is still a challenge. A scalable biomass material, namely cellulose, is reported for customizing anisotropic, all-cellulose, wrinkle-patterned hydrogels (AWHs) through an ultrafast, auxiliary force, acid-induced gradient dual-crosslinking strategy. Direct immersion of a prestretched cellulose alkaline gel in acid and relaxation within seconds allow quick buildup of a consecutive through-thickness modulus gradient with acid-penetration-directed dual-crosslinking, confirmed by visual 3D Raman microscopy imaging, which drives the formation of self-wrinkling structures. Moreover, guided by quantitative mechanics simulations, the structure of AWHs is found to exhibit programmable intervals and aligned nanostructures that differ between ridge and valley regions and can be controlled by tuning the prestretching strain and acid treatment time, and these AWHs successfully induce cell alignment. Thus, a new avenue is opened to fabricate polysaccharide-derived, programmable, anisotropic, wrinkled hydrogels for use as biomedical materials via a bottom-up method
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|a Journal Article
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|a cellulose hydrogels
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|a gradient crosslinking
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|a mechanics simulations
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|a wrinkled patterns
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|a Biocompatible Materials
|2 NLM
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|a Hydrogels
|2 NLM
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|a Cellulose
|2 NLM
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|a 9004-34-6
|2 NLM
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| 700 |
1 |
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|a Wu, Shuangquan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lei, Xiaojuan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Qihua
|e verfasserin
|4 aut
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| 700 |
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|a Yu, Hui
|e verfasserin
|4 aut
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|a Tang, Shan
|e verfasserin
|4 aut
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| 700 |
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|a Ye, Dongdong
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 46 vom: 01. Nov., Seite e1904762
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|g volume:31
|g year:2019
|g number:46
|g day:01
|g month:11
|g pages:e1904762
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|u http://dx.doi.org/10.1002/adma.201904762
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