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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201905091
|2 doi
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|a eng
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| 100 |
1 |
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|a Li, Jingchao
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Near-Infrared Photoactivatable Semiconducting Polymer Nanoblockaders for Metastasis-Inhibited Combination Cancer Therapy
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|c 2019
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|a Text
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 30.03.2020
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Inhibition of protein biosynthesis is a promising strategy to develop new therapeutic modalities for cancers; however, noninvasive precise regulation of this cellular event in living systems has been rarely reported. In this study, a semiconducting polymer nanoblockader (SPNB ) is developed that can inhibit intracellular protein synthesis upon near-infrared (NIR) photoactivation to synergize with photodynamic therapy (PDT) for metastasis-inhibited cancer therapy. SPNB is self-assembled from an amphiphilic semiconducting polymer which is grafted with poly(ethylene glycol) conjugated with a protein biosynthesis blockader through a singlet oxygen (1 O2 ) cleavable linker. Such a designed molecular structure not only enables generation of 1 O2 under NIR photoirradiation for PDT, but also permits photoactivation of blockaders to terminate protein translation. Thereby, SPNB exerts a synergistic action to afford an enhanced therapeutic efficacy in tumor ablation. More importantly, SPNB -mediated photoactivation of protein synthesis inhibition precisely and remotely downregulates the expression levels of metastasis-related proteins in tumor tissues, eventually contributing to the complete inhibition of lung metastasis. This study thus proposes a photoactivatable protherapeutic design for metastasis-inhibited cancer therapy
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|a Journal Article
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|a cancer therapy
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|a metastasis
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| 650 |
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|a organic nanoparticles
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| 650 |
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4 |
|a photoactivation
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| 650 |
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|a prodrugs
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| 650 |
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|a Polymers
|2 NLM
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| 700 |
1 |
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|a Cui, Dong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Yuyan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Jiaguo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cheng, Penghui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pu, Kanyi
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 46 vom: 01. Nov., Seite e1905091
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnas
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| 773 |
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|g volume:31
|g year:2019
|g number:46
|g day:01
|g month:11
|g pages:e1905091
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|u http://dx.doi.org/10.1002/adma.201905091
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