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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.9b01547
|2 doi
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|a pubmed24n1004.xml
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|a DE-627
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Zhou, Wenya
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Thiol-Mediated Multidentate Phosphorylcholine as a Zwitterionic Ligand for Stabilizing Biocompatible Gold Nanoparticles
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 30.06.2020
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|a Date Revised 30.06.2020
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a The increasing application of gold nanoparticles (AuNPs) in biomedicine requires extensive investigation of surface modification and stabilization to maximize their advantages for the diversity of more challenging biological utilization. Herein, a thiol-mediated multifunctional phospholipid ligand was designed while disclosing a zwitterionic nature to AuNPs. The ligand was synthesized by attachment to two bidentate lipoic acid (LA) anchor groups and incorporation of a zwitterionic phosphatidylcholine (PC) group, allowing for excellent hydrophilicity. As demonstrated through ultraviolet-visible spectroscopy, appropriate 7 nm diameter AuNPs modified with a 1,2-dilipoyl-sn-glycero-3-phosphorylcholine (di-LA-PC) compact ligand exhibited the best colloidal stability in a high NaCl concentration of up to 217 mM, different temperatures, and a wide range of pH values from 3 to 11 when compared to the traditional surfactants or thiol-contained amino acid surface modification cases. These AuNPs are also stable without specific interaction to positively/negatively charged proteins, possibly leading to prolonged blood circulation after in vivo administration. Moreover, much more resistance to ligand competition of dithiothreitol was found than other thiol-coated AuNPs, which further highlighted their affinity in an aqueous system. Biocompatibility of the zwitterionic ligand di-LA-PC-modified AuNPs was finally evaluated by hemolysis and cytotoxicity tests. Cumulatively, the remarkable stability and biocompatibility of AuNPs, multicoordinated with a di-LA-PC ligand, potentially motivated them as a practical alternative for surface tailoring in biotechnology
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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1 |
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|a Ling, Longbing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Du, Yawei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a He, Wei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xia, Qing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yao, Chen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xinsong
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 40 vom: 08. Okt., Seite 13031-13039
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:35
|g year:2019
|g number:40
|g day:08
|g month:10
|g pages:13031-13039
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|u http://dx.doi.org/10.1021/acs.langmuir.9b01547
|3 Volltext
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