The H3K4 demethylase Jar1 orchestrates ROS production and expression of pathogenesis-related genes to facilitate Botrytis cinerea virulence

The H3K4 demethylase Jar1 orchestrates ROS production and expression of pathogenesis-related genes to facilitate Botrytis cinerea virulence

© 2019 The Authors. New Phytologist © 2019 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 225(2020), 2 vom: 16. Jan., Seite 930-947
1. Verfasser: Hou, Jie (VerfasserIn)
Weitere Verfasser: Feng, Hui-Qiang, Chang, Hao-Wu, Liu, Yue, Li, Gui-Hua, Yang, Song, Sun, Chen-Hao, Zhang, Ming-Zhe, Yuan, Ye, Sun, Jiao, Zhu-Salzman, Keyan, Zhang, Hao, Qin, Qing-Ming
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Botrytis cinerea H3K4 demethylase JARID1(Jar1) KDM5 cAMP signalling development and pathogenesis infection structures reactive oxygen species (ROS) septin proteins mehr... stress adaptation Fungal Proteins Histones Reactive Oxygen Species histone H3 trimethyl Lys4 Cyclic AMP E0399OZS9N Oxygen S88TT14065
LEADER 01000naa a22002652 4500
001 NLM301378215
003 DE-627
005 20231225104511.0
007 cr uuu---uuuuu
008 231225s2020 xx |||||o 00| ||eng c
024 7 |a 10.1111/nph.16200  |2 doi 
028 5 2 |a pubmed24n1004.xml 
035 |a (DE-627)NLM301378215 
035 |a (NLM)31529514 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a eng 
100 1 |a Hou, Jie  |e verfasserin  |4 aut 
245 1 4 |a The H3K4 demethylase Jar1 orchestrates ROS production and expression of pathogenesis-related genes to facilitate Botrytis cinerea virulence 
264 1 |c 2020 
336 |a Text  |b txt  |2 rdacontent 
337 |a ƒaComputermedien  |b c  |2 rdamedia 
338 |a ƒa Online-Ressource  |b cr  |2 rdacarrier 
500 |a Date Completed 01.12.2020 
500 |a Date Revised 01.12.2020 
500 |a published: Print-Electronic 
500 |a Citation Status MEDLINE 
520 |a © 2019 The Authors. New Phytologist © 2019 New Phytologist Trust. 
520 |a Histone 3 Lysine 4 (H3K4) demethylation is ubiquitous in organisms, however the roles of H3K4 demethylase JARID1(Jar1)/KDM5 in fungal development and pathogenesis remain largely unexplored. Here, we demonstrate that Jar1/KDM5 in Botrytis cinerea, the grey mould fungus, plays a crucial role in these processes. The BcJAR1 gene was deleted and its roles in fungal development and pathogenesis were investigated using approaches including genetics, molecular/cell biology, pathogenicity and transcriptomic profiling. BcJar1 regulates H3K4me3 and both H3K4me2 and H3K4me3 methylation levels during vegetative and pathogenic development, respectively. Loss of BcJAR1 impairs conidiation, appressorium formation and stress adaptation; abolishes infection cushion (IC) formation and virulence, but promotes sclerotium production in the ΔBcjar1 mutants. BcJar1 controls reactive oxygen species (ROS) production and proper assembly of Sep4, a core septin protein and virulence determinant, to initiate infection structure (IFS) formation and host penetration. Exogenous cAMP partially restored the mutant appressorium, but not IC, formation. BcJar1 orchestrates global expression of genes for ROS production, stress response, carbohydrate transmembrane transport, secondary metabolites, etc., which may be required for conidiation, IFS formation, host penetration and virulence of the pathogen. Our work systematically elucidates BcJar1 functions and provides novel insights into Jar1/KDM5-mediated H3K4 demethylation in regulating fungal development and pathogenesis 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Botrytis cinerea 
650 4 |a H3K4 demethylase JARID1(Jar1) 
650 4 |a KDM5 
650 4 |a cAMP signalling 
650 4 |a development and pathogenesis 
650 4 |a infection structures 
650 4 |a reactive oxygen species (ROS) 
650 4 |a septin proteins 
650 4 |a stress adaptation 
650 7 |a Fungal Proteins  |2 NLM 
650 7 |a Histones  |2 NLM 
650 7 |a Reactive Oxygen Species  |2 NLM 
650 7 |a histone H3 trimethyl Lys4  |2 NLM 
650 7 |a Cyclic AMP  |2 NLM 
650 7 |a E0399OZS9N  |2 NLM 
650 7 |a Oxygen  |2 NLM 
650 7 |a S88TT14065  |2 NLM 
700 1 |a Feng, Hui-Qiang  |e verfasserin  |4 aut 
700 1 |a Chang, Hao-Wu  |e verfasserin  |4 aut 
700 1 |a Liu, Yue  |e verfasserin  |4 aut 
700 1 |a Li, Gui-Hua  |e verfasserin  |4 aut 
700 1 |a Yang, Song  |e verfasserin  |4 aut 
700 1 |a Sun, Chen-Hao  |e verfasserin  |4 aut 
700 1 |a Zhang, Ming-Zhe  |e verfasserin  |4 aut 
700 1 |a Yuan, Ye  |e verfasserin  |4 aut 
700 1 |a Sun, Jiao  |e verfasserin  |4 aut 
700 1 |a Zhu-Salzman, Keyan  |e verfasserin  |4 aut 
700 1 |a Zhang, Hao  |e verfasserin  |4 aut 
700 1 |a Qin, Qing-Ming  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t The New phytologist  |d 1979  |g 225(2020), 2 vom: 16. Jan., Seite 930-947  |w (DE-627)NLM09818248X  |x 1469-8137  |7 nnns 
773 1 8 |g volume:225  |g year:2020  |g number:2  |g day:16  |g month:01  |g pages:930-947 
856 4 0 |u http://dx.doi.org/10.1111/nph.16200  |3 Volltext 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 225  |j 2020  |e 2  |b 16  |c 01  |h 930-947