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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.9b02175
|2 doi
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|a pubmed24n1003.xml
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|a (DE-627)NLM301193908
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|a (NLM)31510749
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Zhang, Shan
|e verfasserin
|4 aut
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| 245 |
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|a Peripheral Antimicrobial Peptide Gomesin Induces Membrane Protrusion, Folding, and Laceration
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 21.09.2020
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|a Date Revised 21.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Optical microscopy shows that the peripheral antimicrobial peptide (AMP) gomesin does not disrupt the bacterial membrane by forming stable transmembrane pores but induces lipid accumulation domains, which is followed by a sudden burst near the domains. The molecular action mechanisms of gomesin on vesicle and planar bilayer membranes are investigated in this work using coarse-grained molecular dynamics simulations. By comparing the membrane morphology and property changes induced by gomesin and the pore-forming AMP melittin, we determined that the amphiphilic shape of the AMPs is a key factor affecting the mechanism of cell death. The binding of wedge-shaped gomesin, with a small hydrophobic surface, onto the membrane induces protrusion and folding of the outer monolayer followed by sudden membrane lacerations at the axillae of the protuberances. Alternatively, cylinder-shaped melittins with comparable hydrophilic and hydrophobic surfaces destroy membranes by forming stable pores coexisting with exocytosis-like buddings and endocytosis-like invaginations. The multiple actions of AMPs on the bacterial membrane suggest diverse paradigms for designing molecular carriers for delivering drugs to the cell
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Anti-Bacterial Agents
|2 NLM
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|a Antimicrobial Cationic Peptides
|2 NLM
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|a Lipid Bilayers
|2 NLM
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|a Liposomes
|2 NLM
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|a gomesin
|2 NLM
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|a Melitten
|2 NLM
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| 650 |
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|a 20449-79-0
|2 NLM
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| 700 |
1 |
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|a Fu, Lei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wan, Mingwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Song, Junjie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gao, Lianghui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fang, Weihai
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 40 vom: 08. Okt., Seite 13233-13242
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:35
|g year:2019
|g number:40
|g day:08
|g month:10
|g pages:13233-13242
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|u http://dx.doi.org/10.1021/acs.langmuir.9b02175
|3 Volltext
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