Fibrillar and Nonfibrillar Amyloid Beta Structures Drive Two Modes of Membrane-Mediated Toxicity
In Alzheimer's disease, the amyloid-beta peptide (Aβ) is implicated in neuronal toxicity via interactions with the cell membrane. Monomeric Aβ (Aβm) is intrinsically disordered, but it can adopt a range of aggregated conformations with varying toxicities from short fibrillar oligomers (FO), to...
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Bibliographische Detailangaben
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1999. - 35(2019), 48 vom: 03. Dez., Seite 16024-16036
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| 1. Verfasser: |
Vander Zanden, Crystal M
(VerfasserIn) |
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| Weitere Verfasser: |
Wampler, Lois,
Bowers, Isabella,
Watkins, Erik B,
Majewski, Jaroslaw,
Chi, Eva Y |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2019
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids
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| Schlagworte: | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Amyloid beta-Peptides
Anions
Membranes, Artificial
Phospholipids |
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