No excessive mutations in transcription activator-like effector nuclease-mediated α-1,3-galactosyltransferase knockout Yucatan miniature pigs

OBJECTIVE: Specific genomic sites can be recognized and permanently modified by genome editing. The discovery of endonucleases has advanced genome editing in pigs, attenuating xenograft rejection and cross-species disease transmission. However, off-target mutagenesis caused by these nucleases is a m...

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Veröffentlicht in:	Asian-Australasian journal of animal sciences. - 1998. - 33(2020), 2 vom: 10. Feb., Seite 360-372
1. Verfasser:	Choi, Kimyung (VerfasserIn)
Weitere Verfasser:	Shim, Joohyun, Ko, Nayoung, Park, Joonghoon
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2020
Zugriff auf das übergeordnete Werk:	Asian-Australasian journal of animal sciences
Schlagworte:	Journal Article Off-target RNA Sequencing Transcription Activator-like Effector Nuclease (TALEN) Whole-genome Sequencing Yucatan Miniature Pig α-1,3-Galactosyltransferase (GGTA1)