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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.organomet.9b00457
|2 doi
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|a eng
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| 100 |
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|a van Putten, Robbert
|e verfasserin
|4 aut
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| 245 |
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|a Mechanistic Complexity of Asymmetric Transfer Hydrogenation with Simple Mn-Diamine Catalysts
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Revised 13.10.2023
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a The catalytic asymmetric transfer hydrogenation (ATH) of ketones is a powerful methodology for the practical and efficient installation of chiral centers. Herein, we describe the synthesis, characterization, and catalytic application of a series of manganese complexes bearing simple chiral diamine ligands. We performed an extensive experimental and computational mechanistic study and present the first detailed experimental kinetic study of Mn-catalyzed ATH. We demonstrate that conventional mechanistic approaches toward catalyst optimization fail and how apparently different precatalysts lead to identical intermediates and thus catalytic performance. Ultimately, the Mn-N,N complexes under study enable quantitative ATH of acetophenones to the corresponding chiral alcohols with 75-87% ee
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|a Journal Article
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|a Filonenko, Georgy A
|e verfasserin
|4 aut
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|a Gonzalez de Castro, Angela
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Chong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Weber, Manuela
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Müller, Christian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lefort, Laurent
|e verfasserin
|4 aut
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| 700 |
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|a Pidko, Evgeny
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Organometallics
|d 1998
|g 38(2019), 16 vom: 26. Aug., Seite 3187-3196
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|x 0276-7333
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|g volume:38
|g year:2019
|g number:16
|g day:26
|g month:08
|g pages:3187-3196
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|u http://dx.doi.org/10.1021/acs.organomet.9b00457
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