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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2019.108253
|2 doi
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|a pubmed24n1002.xml
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|a (DE-627)NLM300793995
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|a (NLM)31470086
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|a (PII)S1521-6616(19)30351-1
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Bridgewood, Charlie
|e verfasserin
|4 aut
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| 245 |
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|a The novel cytokine Metrnl/IL-41 is elevated in Psoriatic Arthritis synovium and inducible from both entheseal and synovial fibroblasts
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 19.05.2020
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|a Date Revised 02.11.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2019 Elsevier Inc. All rights reserved.
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|a Meteorin-like(IL-41), is a novel cytokine that is thought to be immunoregulatory and is highly expressed in psoriatic skin. We investigated IL-41 protein expression in synovial tissue in RA(Rheumatoid Arthritis), PsA(Psoriatic Arthritis) and OA(Osteoarthritis) patients and evaluated IL-41 production from healthy enthesis samples, as the enthesis represent the primary inflammatory site in PsA. IL-41 was measured in synovial fluid from PsA, RA and OA patients. Synovial biopsies were stained for IL-41 by immunohistochemistry. IL-41 was highly expressed in the synovial fluid and synovial tissue of PsA patients (median = 7722 pg/ml) when compared to OA patients (median = 5044 pg/ml). We found that entheseal stromal cells were the dominant producer of IL-41 from the enthesis. Moreover, stromal derived IL-41, could be further induced by IL-17A/F and TNF. In conclusion, IL-41 is expressed in PsA synovium and is present and inducible at the enthesis. Its functional effect in psoriatic inflammation remains to be fully elucidated
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Cytokine
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| 650 |
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|a Enthesitis
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| 650 |
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|a Inflammation
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| 650 |
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|a Psoriatic arthritis
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| 650 |
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|a Spondyloarthritis
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| 650 |
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|a Synovium
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| 650 |
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|a Adipokines
|2 NLM
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| 650 |
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|a Metrnl protein, human
|2 NLM
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| 700 |
1 |
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|a Russell, Tobias
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Weedon, Helen
|e verfasserin
|4 aut
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| 700 |
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|a Baboolal, Thomas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Watad, Abdulla
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sharif, Kassem
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cuthbert, Richard
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wittmann, Miriam
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wechalekar, Mihir
|e verfasserin
|4 aut
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| 700 |
1 |
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|a McGonagle, Dennis
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 208(2019) vom: 10. Nov., Seite 108253
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:208
|g year:2019
|g day:10
|g month:11
|g pages:108253
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2019.108253
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_ILN_11
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|a GBV_ILN_24
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|a AR
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