Calcium-dependent protein kinase 5 links calcium signaling with N-hydroxy-l-pipecolic acid- and SARD1-dependent immune memory in systemic acquired resistance

Calcium-dependent protein kinase 5 links calcium signaling with N-hydroxy-l-pipecolic acid- and SARD1-dependent immune memory in systemic acquired resistance

© 2019 The Authors. New Phytologist © 2019 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 225(2020), 1 vom: 15. Jan., Seite 310-325
1. Verfasser: Guerra, Tiziana (VerfasserIn)
Weitere Verfasser: Schilling, Silke, Hake, Katharina, Gorzolka, Karin, Sylvester, Fabian-Philipp, Conrads, Benjamin, Westermann, Bernhard, Romeis, Tina
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2020
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't N-hydroxy-l-pipecolic acid SARD1 calcium signaling calcium-dependent protein kinase 5 immune memory systemic acquired resistance Arabidopsis Proteins Pipecolic Acids mehr... SARD1 protein, Arabidopsis CPK5 protein, Arabidopsis EC 2.7.11.17 Calcium-Calmodulin-Dependent Protein Kinases pipecolic acid H254GW7PVV Salicylic Acid O414PZ4LPZ Calcium SY7Q814VUP
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520 |a Systemic acquired resistance (SAR) prepares infected plants for faster and stronger defense activation upon subsequent attacks. SAR requires an information relay from primary infection to distal tissue and the initiation and maintenance of a self-maintaining phytohormone salicylic acid (SA)-defense loop. In spatial and temporal resolution, we show that calcium-dependent protein kinase CPK5 contributes to immunity and SAR. In local basal resistance, CPK5 functions upstream of SA synthesis, perception, and signaling. In systemic tissue, CPK5 signaling leads to accumulation of SAR-inducing metabolite N-hydroxy-L-pipecolic acid (NHP) and SAR marker genes, including Systemic Acquired Resistance Deficient 1 (SARD1) Plants of increased CPK5, but not CPK6, signaling display an 'enhanced SAR' phenotype towards a secondary bacterial infection. In the sard1-1 background, CPK5-mediated basal resistance is still mounted, but NHP concentration is reduced and enhanced SAR is lost. The biochemical analysis estimated CPK5 half maximal kinase activity for calcium, K50 [Ca2+ ], to be c. 100 nM, close to the cytoplasmic resting level. This low threshold uniquely qualifies CPK5 to decode subtle changes in calcium, a prerequisite to signal relay and onset and maintenance of priming at later time points in distal tissue. Our data explain why CPK5 functions as a hub in basal and systemic plant immunity 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a N-hydroxy-l-pipecolic acid 
650 4 |a SARD1 
650 4 |a calcium signaling 
650 4 |a calcium-dependent protein kinase 5 
650 4 |a immune memory 
650 4 |a systemic acquired resistance 
650 7 |a Arabidopsis Proteins  |2 NLM 
650 7 |a Pipecolic Acids  |2 NLM 
650 7 |a SARD1 protein, Arabidopsis  |2 NLM 
650 7 |a CPK5 protein, Arabidopsis  |2 NLM 
650 7 |a EC 2.7.11.17  |2 NLM 
650 7 |a Calcium-Calmodulin-Dependent Protein Kinases  |2 NLM 
650 7 |a EC 2.7.11.17  |2 NLM 
650 7 |a pipecolic acid  |2 NLM 
650 7 |a H254GW7PVV  |2 NLM 
650 7 |a Salicylic Acid  |2 NLM 
650 7 |a O414PZ4LPZ  |2 NLM 
650 7 |a Calcium  |2 NLM 
650 7 |a SY7Q814VUP  |2 NLM 
700 1 |a Schilling, Silke  |e verfasserin  |4 aut 
700 1 |a Hake, Katharina  |e verfasserin  |4 aut 
700 1 |a Gorzolka, Karin  |e verfasserin  |4 aut 
700 1 |a Sylvester, Fabian-Philipp  |e verfasserin  |4 aut 
700 1 |a Conrads, Benjamin  |e verfasserin  |4 aut 
700 1 |a Westermann, Bernhard  |e verfasserin  |4 aut 
700 1 |a Romeis, Tina  |e verfasserin  |4 aut 
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773 1 8 |g volume:225  |g year:2020  |g number:1  |g day:15  |g month:01  |g pages:310-325 
856 4 0 |u http://dx.doi.org/10.1111/nph.16147  |3 Volltext 
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