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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2019.108252
|2 doi
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|a pubmed24n1001.xml
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|a (DE-627)NLM300595131
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|a (NLM)31449879
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|a (PII)S1521-6616(19)30257-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
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|a Takakura, Maiko
|e verfasserin
|4 aut
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|a Comparison of serum biomarkers for the diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 19.05.2020
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|a Date Revised 19.05.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2019 Elsevier Inc. All rights reserved.
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|a Our study aimed to compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (s-JIA). Serum cytokine levels (neopterin, IL-18, and CXCL9 and soluble tumor necrosis factor receptor type I (sTNFR-I) and II) were determined by enzyme-linked immunosorbent assay in 78 patients with s-JIA, including 21 with MAS. Receiver operating characteristic curve analysis revealed area under the curve values and cut off values of neopterin, IL-18, CXCL9, sTNFR-II/I ratio and ferritin were 0.9465/19.5 nmol/l, 0.8895/69250 ng/ml, 0.9333/3130 pg/ml, 0.9395/3.796 and 0.8671/2560 ng/ml, respectively. Serum neopterin levels were significantly elevated in patients with MAS and those were correlated positively with disease activity. In conclusion, serum neopterin levels may be used as a promising indicator of disease activity in s-JIA and MAS and for evaluating it. It may also be a useful marker to diagnose the transition to MAS from active-phase s-JIA
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|a Comparative Study
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Macrophage activation syndrome
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|a Neopterin
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|a Systemic juvenile idiopathic arthritis
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| 650 |
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|a Biomarkers
|2 NLM
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| 650 |
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|a Neopterin
|2 NLM
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| 650 |
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|a 670-65-5
|2 NLM
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| 700 |
1 |
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|a Shimizu, Masaki
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Irabu, Hitoshi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sakumura, Naoto
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Inoue, Natsumi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mizuta, Mao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nakagishi, Yasuo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yachie, Akihiro
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 208(2019) vom: 01. Nov., Seite 108252
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:208
|g year:2019
|g day:01
|g month:11
|g pages:108252
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|u http://dx.doi.org/10.1016/j.clim.2019.108252
|3 Volltext
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