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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201803474
|2 doi
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|a eng
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| 100 |
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|a All, Angelo Homayoun
|e verfasserin
|4 aut
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| 245 |
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|a Expanding the Toolbox of Upconversion Nanoparticles for In Vivo Optogenetics and Neuromodulation
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|c 2019
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|a Text
|b txt
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 17.02.2020
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Optogenetics is an optical technique that exploits visible light for selective neuromodulation with spatio-temporal precision. Despite enormous effort, the effective stimulation of targeted neurons, which are located in deeper structures of the nervous system, by visible light, remains a technical challenge. Compared to visible light, near-infrared illumination offers a higher depth of tissue penetration owing to a lower degree of light attenuation. Herein, an overview of advances in developing new modalities for neural circuitry modulation utilizing upconversion-nanoparticle-mediated optogenetics is presented. These developments have led to minimally invasive optical stimulation and inhibition of neurons with substantially improved selectivity, sensitivity, and spatial resolution. The focus is to provide a comprehensive review of the mechanistic basis for evaluating upconversion parameters, which will be useful in designing, executing, and reporting optogenetic experiments
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|a Journal Article
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|a Review
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|a in vivo optogenetics
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|a near-infrared light
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|a noninvasive neuromodulation
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| 650 |
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|a upconversion nanoparticles
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| 700 |
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|a Zeng, Xiao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Teh, Daniel Boon Loong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yi, Zhigao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Prasad, Ankshita
|e verfasserin
|4 aut
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| 700 |
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|a Ishizuka, Toru
|e verfasserin
|4 aut
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|a Thakor, Nitish
|e verfasserin
|4 aut
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|a Hiromu, Yawo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Xiaogang
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 41 vom: 08. Okt., Seite e1803474
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|x 1521-4095
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|g volume:31
|g year:2019
|g number:41
|g day:08
|g month:10
|g pages:e1803474
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|u http://dx.doi.org/10.1002/adma.201803474
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