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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/erz260
|2 doi
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|a pubmed25n1000.xml
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|e rakwb
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|a eng
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1 |
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|a Watanabe, Mutsumi
|e verfasserin
|4 aut
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| 245 |
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|a Sulphur systems biology-making sense of omics data
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 16.07.2020
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|a Date Revised 13.10.2023
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|a published: Print
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|a Citation Status MEDLINE
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|a © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Experimental Biology.
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|a Systems biology approaches have been applied over the last two decades to study plant sulphur metabolism. These 'sulphur-omics' approaches have been developed in parallel with the advancing field of systems biology, which is characterized by permanent improvements of high-throughput methods to obtain system-wide data. The aim is to obtain a holistic view of sulphur metabolism and to generate models that allow predictions of metabolic and physiological responses. Besides known sulphur-responsive genes derived from previous studies, numerous genes have been identified in transcriptomics studies. This has not only increased our knowledge of sulphur metabolism but has also revealed links between metabolic processes, thus indicating a previously unexpected complex interconnectivity. The identification of response and control networks has been supported through metabolomics and proteomics studies. Due to the complex interlacing nature of biological processes, experimental validation using targeted or systems approaches is ongoing. There is still room for improvement in integrating the findings from studies of metabolomes, proteomes, and metabolic fluxes into a single unifying concept and to generate consistent models. We therefore suggest a joint effort of the sulphur research community to standardize data acquisition. Furthermore, focusing on a few different model plant systems would help overcome the problem of fragmented data, and would allow us to provide a standard data set against which future experiments can be designed and compared
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a Arabidopsis
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|a metabolomics
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| 650 |
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|a plant systems
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| 650 |
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|a proteomics
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| 650 |
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4 |
|a sulphur metabolism
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| 650 |
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4 |
|a systems biology
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| 650 |
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|a transcriptomics
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| 650 |
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|a Plant Proteins
|2 NLM
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| 650 |
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|a Proteome
|2 NLM
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| 650 |
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|a Sulfur
|2 NLM
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| 650 |
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|a 70FD1KFU70
|2 NLM
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| 700 |
1 |
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|a Hoefgen, Rainer
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 70(2019), 16 vom: 19. Aug., Seite 4155-4170
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnns
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|g volume:70
|g year:2019
|g number:16
|g day:19
|g month:08
|g pages:4155-4170
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|u http://dx.doi.org/10.1093/jxb/erz260
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