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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1021/acs.langmuir.9b01542
|2 doi
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|a pubmed24n0998.xml
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|a (DE-627)NLM299424812
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|a (NLM)31330110
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Chervy, Pierre
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Organic Nanoscrolls from Electrostatic Interactions between Peptides and Lipids
|b Assembly Steps and Structure
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 13.08.2020
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|a Date Revised 13.08.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a An important aspect of cells is their shape flexibility that gives them motion but also a high adaptation versatility to their environment. This shape versatility is mediated by different types of protein-membrane interactions among which electrostatic plays an important role. In the present work we examined the interaction between a small dicationic peptide, that possesses self-assembly properties, and lipid model membranes. The peptide, lanreotide, spontaneously forms nanotubes in water that have a strictly uniform diameter. In the current work, we show that the interaction between the cationic peptide and negatively charged bilayers of lipids induces the formation of myelin sheath-like structures that we call nanoscrolls. By deciphering the different steps of formation and the molecular structure of the self-assembly, we show how electrostatics modify the spontaneous peptide and lipid way of packing
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Lipid Bilayers
|2 NLM
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|a Peptides, Cyclic
|2 NLM
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| 650 |
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|a Phosphatidylglycerols
|2 NLM
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| 650 |
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|a lanreotide
|2 NLM
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| 650 |
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7 |
|a 0G3DE8943Y
|2 NLM
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|a Somatostatin
|2 NLM
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|a 51110-01-1
|2 NLM
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| 700 |
1 |
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|a Petcut, Cristina
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rault, Damien
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Meriadec, Cristelle
|e verfasserin
|4 aut
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| 700 |
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|a Bizien, Thomas
|e verfasserin
|4 aut
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| 700 |
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|a François, Keinny
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Richard, Joel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chassaing, Christophe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Benamar, Naziha
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Artzner, Franck
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Paternostre, Maïté
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 32 vom: 13. Aug., Seite 10648-10657
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:35
|g year:2019
|g number:32
|g day:13
|g month:08
|g pages:10648-10657
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|u http://dx.doi.org/10.1021/acs.langmuir.9b01542
|3 Volltext
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|h 10648-10657
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