Clinical manifestations and gastrointestinal pathology in 40 patients with autoimmune enteropathy

Clinical manifestations and gastrointestinal pathology in 40 patients with autoimmune enteropathy

Copyright © 2019 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 207(2019) vom: 15. Okt., Seite 10-17
1. Verfasser: Villanacci, Vincenzo (VerfasserIn)
Weitere Verfasser: Lougaris, Vassilios, Ravelli, Alberto, Buscarini, Elisabetta, Salviato, Tiziana, Lionetti, Paolo, Salemme, Marianna, Martelossi, Stefano, De Giacomo, Costantino, Falchetti, Diego, Pelizzo, Gloria, Bassotti, Gabrio
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Autoimmune enteropathy (AIE) Celiac disease Duodenum Primary immunodeficiencies (PIDs)
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520 |a Autoimmune enteropathy (AIE) is a rare condition that may affect pediatric and adult patients, frequently associated with primary immunodeficiencies. We performed a retrospective study on clinical and histological findings from 40 AIE patients. Histological presentation showed a prevalent celiac disease pattern (50%), followed by the mixed pattern (35%), independently of age, chronic active duodenitis (10%), and GVHD-like pattern (5%). Patients with primary immunodeficiencies (24/40) presented mainly with the celiac disease pattern (72.2% versus 22.2%; p < .0001), while patients without primary immunodeficiencies presented with a mixed histological pattern (61.1% versus 13.6%; p < .0001). Our study shows that the prevalent histological presentation is the celiac disease-like pattern, independently of age, and, for the first time, that the histological presentation of AIE differs significantly between patients with and without primary immunodeficiencies. These findings may be helpful for more precise and timely diagnosis and management of this rare disorder 
650 4 |a Journal Article 
650 4 |a Autoimmune enteropathy (AIE) 
650 4 |a Celiac disease 
650 4 |a Duodenum 
650 4 |a Primary immunodeficiencies (PIDs) 
700 1 |a Lougaris, Vassilios  |e verfasserin  |4 aut 
700 1 |a Ravelli, Alberto  |e verfasserin  |4 aut 
700 1 |a Buscarini, Elisabetta  |e verfasserin  |4 aut 
700 1 |a Salviato, Tiziana  |e verfasserin  |4 aut 
700 1 |a Lionetti, Paolo  |e verfasserin  |4 aut 
700 1 |a Salemme, Marianna  |e verfasserin  |4 aut 
700 1 |a Martelossi, Stefano  |e verfasserin  |4 aut 
700 1 |a De Giacomo, Costantino  |e verfasserin  |4 aut 
700 1 |a Falchetti, Diego  |e verfasserin  |4 aut 
700 1 |a Pelizzo, Gloria  |e verfasserin  |4 aut 
700 1 |a Bassotti, Gabrio  |e verfasserin  |4 aut 
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