An Acidic-Microenvironment-Driven DNA Nanomachine Enables Specific ATP Imaging in the Extracellular Milieu of Tumor

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 31(2019), 33 vom: 01. Aug., Seite e1901885
1. Verfasser: Di, Zhenghan (VerfasserIn)
Weitere Verfasser: Zhao, Jian, Chu, Hongqian, Xue, Wenting, Zhao, Yuliang, Li, Lele
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article DNA nanomachines cancer treatment extracellular ATP imaging tumor microenvironment Aptamers, Nucleotide Fluorescent Dyes Peptides Bacteriorhodopsins mehr... 53026-44-1 Adenosine Triphosphate 8L70Q75FXE DNA 9007-49-2
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245 1 3 |a An Acidic-Microenvironment-Driven DNA Nanomachine Enables Specific ATP Imaging in the Extracellular Milieu of Tumor 
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500 |a Citation Status MEDLINE 
520 |a © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 
520 |a Extracellular ATP is an emerging target for cancer treatment because it is a key messenger for shaping the tumor microenvironment (TME) and regulating tumor progression. However, it remains a great challenge to design biochemical probes for targeted imaging of extracellular ATP in the TME. A TME-driven DNA nanomachine (Apt-LIP) that permits spatially controlled imaging of ATP in the extracellular milieu of tumors with ultrahigh signal-to-background ratio is reported. It operates in response to the mild acidity in the TME with the pH (low) insertion peptide (pHLIP) module, thus allowing the specific anchoring of the structure-switching signaling aptamer unit to the membrane of tumor cells for "off-on" fluorescence imaging of the extracellular ATP. Apt-LIP allows for acidity driven visualization of different extracellular concentrations of exogenous ATP, as well as the monitoring of endogenous ATP release from cells. Furthermore, it is demonstrated that Apt-LIP represents a promising platform for the specific imaging of the extracellular ATP in both primary and metastatic tumors. Ultimately, since diverse aptamers are obtained through in vitro selection, this design strategy can be further applied for precise detection of various extracellular targets in the TME 
650 4 |a Journal Article 
650 4 |a DNA nanomachines 
650 4 |a cancer treatment 
650 4 |a extracellular ATP 
650 4 |a imaging 
650 4 |a tumor microenvironment 
650 7 |a Aptamers, Nucleotide  |2 NLM 
650 7 |a Fluorescent Dyes  |2 NLM 
650 7 |a Peptides  |2 NLM 
650 7 |a Bacteriorhodopsins  |2 NLM 
650 7 |a 53026-44-1  |2 NLM 
650 7 |a Adenosine Triphosphate  |2 NLM 
650 7 |a 8L70Q75FXE  |2 NLM 
650 7 |a DNA  |2 NLM 
650 7 |a 9007-49-2  |2 NLM 
700 1 |a Zhao, Jian  |e verfasserin  |4 aut 
700 1 |a Chu, Hongqian  |e verfasserin  |4 aut 
700 1 |a Xue, Wenting  |e verfasserin  |4 aut 
700 1 |a Zhao, Yuliang  |e verfasserin  |4 aut 
700 1 |a Li, Lele  |e verfasserin  |4 aut 
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773 1 8 |g volume:31  |g year:2019  |g number:33  |g day:01  |g month:08  |g pages:e1901885 
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