Enhancing Prostate-Cancer-Specific MRI by Genetic Amplified Nanoparticle Tumor Homing

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 31(2019), 30 vom: 11. Juli, Seite e1900928
1. Verfasser: Zhao, Yang (VerfasserIn)
Weitere Verfasser: Peng, Jing, Yang, Jinyi, Zhang, Enlong, Huang, Ling, Yang, Hong, Kakadiaris, Eugenia, Li, Jingjin, Yan, Bin, Shang, Zhiqun, Jiang, Ning, Zhang, Xuening, Han, Gang, Niu, Yuanjie
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article genetic probes magnetic resonance imaging nanomedicine prostate cancer transferrin tumor-targeting Magnetite Nanoparticles Receptors, Transferrin Transferrin
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520 |a Precise localization and visualization of early-stage prostate cancer (PCa) is critical to improve the success of focal ablation and reduce cancer mortality. However, it remains challenging under the current imaging techniques due to the heterogeneous nature of PCa and the suboptimal sensitivity of the techniques themselves. Herein, a novel genetic amplified nanoparticle tumor-homing strategy to enhance the MRI accuracy of ultrasmall PCa lesions is reported. This strategy could specifically drive TfR expressions in PCa under PCa-specific DD3 promoter, and thus remarkably increase Tf-USPIONs concentrations in a highly accurate manner while minimizing their non-specific off-target effects on normal tissues. Consequently, this strategy can pinpoint an ultrasmall PCa lesion, which is otherwise blurred in the current MRI, and thereby addresses the unmet key need in MRI imaging for focal therapy. With this proof-of-concept experiment, the synergistic gene-nano strategy holds great promise to boost the MRI effects of a wide variety of commonly used nanoscale and molecular probes that are otherwise limited. In addition, such a strategy may also be translated and applied to MR-specific imaging of other types of cancers by using their respective tumor-specific promoters 
650 4 |a Journal Article 
650 4 |a genetic probes 
650 4 |a magnetic resonance imaging 
650 4 |a nanomedicine 
650 4 |a prostate cancer 
650 4 |a transferrin 
650 4 |a tumor-targeting 
650 7 |a Magnetite Nanoparticles  |2 NLM 
650 7 |a Receptors, Transferrin  |2 NLM 
650 7 |a Transferrin  |2 NLM 
700 1 |a Peng, Jing  |e verfasserin  |4 aut 
700 1 |a Yang, Jinyi  |e verfasserin  |4 aut 
700 1 |a Zhang, Enlong  |e verfasserin  |4 aut 
700 1 |a Huang, Ling  |e verfasserin  |4 aut 
700 1 |a Yang, Hong  |e verfasserin  |4 aut 
700 1 |a Kakadiaris, Eugenia  |e verfasserin  |4 aut 
700 1 |a Li, Jingjin  |e verfasserin  |4 aut 
700 1 |a Yan, Bin  |e verfasserin  |4 aut 
700 1 |a Shang, Zhiqun  |e verfasserin  |4 aut 
700 1 |a Jiang, Ning  |e verfasserin  |4 aut 
700 1 |a Zhang, Xuening  |e verfasserin  |4 aut 
700 1 |a Han, Gang  |e verfasserin  |4 aut 
700 1 |a Niu, Yuanjie  |e verfasserin  |4 aut 
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