|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM297949381 |
| 003 |
DE-627 |
| 005 |
20231225093114.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2019 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/acs.langmuir.9b01325
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0993.xml
|
| 035 |
|
|
|a (DE-627)NLM297949381
|
| 035 |
|
|
|a (NLM)31177786
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Li, Dianqi
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Cross-Linked Poly(ethylene glycol) Shells for Nanoparticles
|b Enhanced Stealth Effect and Colloidal Stability
|
| 264 |
|
1 |
|c 2019
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 26.06.2020
|
| 500 |
|
|
|a Date Revised 26.06.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status PubMed-not-MEDLINE
|
| 520 |
|
|
|a Preventing protein corona formation and macrophage uptake is the key to improving the delivery efficiency of nanocarriers. Herein, we present a kind of cross-linking poly(ethylene glycol) (CL-PEG) shell-wrapped gold nanoparticles (namely, AuCL-PEG NPs), which show much enhanced stealth effect and colloidal stability in physiological environments. Compared to the AuNPs coated with conventional linear PEGs (namely, Au@PEG NPs), Au@CL-PEG NPs have a greater ability to resist protein adsorption and thus show reduced cellular uptake by macrophages. In addition, the Au@CL-PEG NPs show higher chemical and colloidal stability under different extreme conditions than the conventional Au@PEG NPs. The CL-PEGylation strategy provides a new window for the surface functionalization of nanomaterials, indicating great promise for the development of high-performance nanomedicines
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 700 |
1 |
|
|a Wang, Fengchao
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Di, Huixia
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Xuehui
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Pengjuan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhou, Wen
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Dingbin
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 35(2019), 26 vom: 02. Juli, Seite 8799-8805
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:35
|g year:2019
|g number:26
|g day:02
|g month:07
|g pages:8799-8805
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/acs.langmuir.9b01325
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 35
|j 2019
|e 26
|b 02
|c 07
|h 8799-8805
|