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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1111/jfd.13040
|2 doi
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|a pubmed25n0992.xml
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|a eng
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| 100 |
1 |
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|a Rairat, Tirawat
|e verfasserin
|4 aut
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| 245 |
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|a Pharmacokinetic-pharmacodynamic modelling for the determination of optimal dosing regimen of florfenicol in Nile tilapia (Oreochromis niloticus) at different water temperatures and antimicrobial susceptibility levels
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|c 2019
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 05.11.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 John Wiley & Sons Ltd.
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|a Optimized dosing regimen is key to the effective use of antibacterials and to minimizing drug-related side effects. The current study established a pharmacokinetic-pharmacodynamic (PK-PD) model for the determination of optimal antibacterial dosing regimen in fish taken into consideration the temperature-dependent PK and the pathogen-dependent antimicrobial susceptibility, using florfenicol (FF) in Nile tilapia as an example. The calculated optimal dosages significantly varied by temperature and target MIC levels, ranging from 2.23 (MIC 1 µg/ml at 24°C) to 34.88 mg kg-1 day-1 (MIC 4 µg/ml at 32°C). The appropriateness of the calculated dosages was successfully verified by the in vivo studies. After 5 days of oral administration of the calculated optimal dosage at 24°C, the predicted plasma drug values were in line with the mean observed Cmin(ss) while at 28 and 32°C underestimation of the Cmin(ss) in a dose-dependent manner was observed and likely due to the occurrence of non-linear PK at high dosages. The averaged serum protein binding of FF was 19.1%. Our results demonstrated the appropriateness and clinical applicability of the developed PK-PD approach for the determination of optimal dosing regimens at given temperatures and MICs. Saturation metabolism and PK non-linearity of FF in tilapia warrant further study
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|a Journal Article
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|a Nile tilapia
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|a florfenicol
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|a optimal dosing regimen
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|a pharmacokinetic-pharmacodynamic
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|a Anti-Bacterial Agents
|2 NLM
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|a Water
|2 NLM
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| 650 |
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|a 059QF0KO0R
|2 NLM
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| 650 |
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|a florfenicol
|2 NLM
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| 650 |
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|a 9J97307Y1H
|2 NLM
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| 650 |
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|a Thiamphenicol
|2 NLM
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| 650 |
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7 |
|a FLQ7571NPM
|2 NLM
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| 700 |
1 |
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|a Hsieh, Chia-Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Thongpiam, Wipavee
|e verfasserin
|4 aut
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| 700 |
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|a Chou, Chi-Chung
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of fish diseases
|d 1998
|g 42(2019), 8 vom: 03. Aug., Seite 1181-1190
|w (DE-627)NLM098166034
|x 1365-2761
|7 nnns
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| 773 |
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|g volume:42
|g year:2019
|g number:8
|g day:03
|g month:08
|g pages:1181-1190
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|u http://dx.doi.org/10.1111/jfd.13040
|3 Volltext
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