Molecular dynamics simulation of anticancer drug delivery from carbon nanotube using metal nanowires
© 2019 Wiley Periodicals, Inc.
| Veröffentlicht in: | Journal of computational chemistry. - 1984. - 40(2019), 25 vom: 30. Sept., Seite 2179-2190 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2019
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| Zugriff auf das übergeordnete Werk: | Journal of computational chemistry |
| Schlagworte: | Journal Article carbon nanotube cisplatin doping effect drug delivery molecular dynamics simulation nanocluster nanowire Antineoplastic Agents Nanotubes, Carbon mehr... |
| Zusammenfassung: | © 2019 Wiley Periodicals, Inc. In this study, we have investigated delivery of cisplatin as the anticancer drug molecules in different carbon nanotubes (CNTs) in the gas phase using molecular dynamics simulation. We examined the shape and composition of the releasing agent by using the different nanowires and nanoclusters. We also investigated the doping effect on the drug delivery process using N-, Si, B-, and Fe-doped CNTs. Different thermodynamics, structural, and dynamical properties have been studied by using the pure and different doped CNTs in this study. Our results show that the doping of the CNT has significant effect on the rate of the drug releasing process regardless of the composition of the releasing agent. © 2019 Wiley Periodicals, Inc |
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| Beschreibung: | Date Completed 10.08.2020 Date Revised 10.08.2020 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1096-987X |
| DOI: | 10.1002/jcc.25867 |