Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration

Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration

© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 31(2019), 33 vom: 24. Aug., Seite e1900727
1. Verfasser: Xu, Duo (VerfasserIn)
Weitere Verfasser: Wu, Di, Qin, Meng, Nih, Lina R, Liu, Chaoyong, Cao, Zheng, Ren, Jie, Chen, Xiangjun, He, Zhanlong, Yu, Wenhai, Guan, Jiaoqiong, Duan, Suqin, Liu, Fang, Liu, Xiangsheng, Li, Jesse, Harley, Dushawn, Xu, Bin, Hou, Lihua, Chen, Irvin S Y, Wen, Jing, Chen, Wei, Pourtaheri, Sina, Lu, Yunfeng
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article blood-brain barrier central nervous system nerve growth factors neural regeneration spinal cord injury Acrylic Resins Biocompatible Materials Cross-Linking Reagents Methacrylates mehr... Nanocapsules Nerve Growth Factors Polyesters Phosphorylcholine 107-73-3 poly(lactide) 459TN2L5F5 carbopol 940 4Q93RCW27E 2-methacryloyloxyethyl phosphorylcholine 59RU860S8D
Beschreibung
Zusammenfassung:© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
The central nervous system (CNS) plays a central role in the control of sensory and motor functions, and the disruption of its barriers can result in severe and debilitating neurological disorders. Neurotrophins are promising therapeutic agents for neural regeneration in the damaged CNS. However, their penetration across the blood-brain barrier remains a formidable challenge, representing a bottleneck for brain and spinal cord therapy. Herein, a nanocapsule-based delivery system is reported that enables intravenously injected nerve growth factor (NGF) to enter the CNS in healthy mice and nonhuman primates. Under pathological conditions, the delivery of NGF enables neural regeneration, tissue remodeling, and functional recovery in mice with spinal cord injury. This technology can be utilized to deliver other neurotrophins and growth factors to the CNS, opening a new avenue for tissue engineering and the treatment of CNS disorders and neurodegenerative diseases
Beschreibung:Date Completed 27.09.2019
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201900727