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20231225091725.0 |
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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2019.05.010
|2 doi
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|a pubmed24n0991.xml
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|a (DE-627)NLM297311344
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|a (NLM)31112757
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|a (PII)S1521-6616(18)30681-8
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Yu, Xing-Xing
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Delay expression of NKp30 on NK cells correlates with long-term mycophenolate mofetil treatment and higher EBV viremia post allogenic hematological stem cells transplantation
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|c 2019
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 20.04.2020
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|a Date Revised 20.04.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2019 Elsevier Inc. All rights reserved.
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|a Mycophenolate mofetil (MMF) is an immunosuppressive agent that is widely used in graft-versus-host disease prophylaxis because of its inhibitory function on T cells and B cells. However, the effect of MMF on natural killer cell reconstitution after allogenic hematological transplantation is largely unknown. The present study examined the effects of different MMF administration durations after haploidentical allo-HSCT on NK cell reconstitution. Ninety patients were enrolled in this study and defined into two groups in term of MMF duration. We found that MMF patients in the long-term MMF group were associated with a poor reconstitution of NK cells and a significantly lower cytotoxicity from day 30 to day 180 post-transplantation. Especially, the long-term MMF group inhibits reconstitution of NKp30 NK subsets, which correlated with higher risk of EBV viremia. Multivariate analysis showed that a better reconstitution of NKp30 cells was associated with lower EBV viremia (HR0.957, p = .04). In vitro experiments demonstrated that the active metabolite of MMF, mycophenolic acid (MPA), inhibited the proliferation and cytotoxicity of NK cells from healthy donors or patients at day 30 post-transplantation. In summary, our findings demonstrated that long-term MMF administration delayed the quality and quantity of NK cells, especially NKp30 subpopulations, which was associated with decreased EBV viremia post allogeneic HSCT
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Allo-HSCT
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| 650 |
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|a MMF
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| 650 |
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|a NK cells
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| 650 |
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|a NKp30
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| 650 |
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|a Reconstitution
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| 650 |
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|a Immunosuppressive Agents
|2 NLM
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| 650 |
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|a NCR3 protein, human
|2 NLM
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| 650 |
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7 |
|a Natural Cytotoxicity Triggering Receptor 3
|2 NLM
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| 650 |
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|a Mycophenolic Acid
|2 NLM
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| 650 |
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7 |
|a HU9DX48N0T
|2 NLM
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| 700 |
1 |
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|a Cao, Xun-Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yan, Hong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Xue-Yi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Xiao-Su
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Yu-Qian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xu, Lan-Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Xiao-Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chang, Ying-Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huang, Xiao-Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhao, Xiang-Yu
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 205(2019) vom: 01. Aug., Seite 49-56
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:205
|g year:2019
|g day:01
|g month:08
|g pages:49-56
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2019.05.010
|3 Volltext
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 205
|j 2019
|b 01
|c 08
|h 49-56
|