Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response

Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response

© 2019 The Authors. New Phytologist © 2019 New Phytologist Trust.

Bibliographische Detailangaben
Veröffentlicht in:The New phytologist. - 1979. - 223(2019), 3 vom: 30. Aug., Seite 1372-1387
1. Verfasser: Huang, Shuangzhan (VerfasserIn)
Weitere Verfasser: Zhang, Ai, Jin, Jing Bo, Zhao, Bo, Wang, Tian-Jing, Wu, Yifan, Wang, Shuang, Liu, Yutong, Wang, Jie, Guo, Peng, Ahmad, Rafiq, Liu, Bao, Xu, Zheng-Yi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2019
Zugriff auf das übergeordnete Werk:The New phytologist
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Arabidopsis thaliana abiotic stress abscisic acid (ABA) dehydration stress histone demethylation transcriptional regulation Arabidopsis Proteins Chromatin
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520 |a Under dehydration in plants, antagonistic activities of histone 3 lysine 4 (H3K4) methyltransferase and histone demethylase maintain a dynamic and homeostatic state of gene expression by orientating transcriptional reprogramming toward growth or stress tolerance. However, the histone demethylase that specifically controls histone methylation homeostasis under dehydration stress remains unknown. Here, we document that a histone demethylase, JMJ17, belonging to the KDM5/JARID1 family, plays crucial roles in response to dehydration stress and abscisic acid (ABA) in Arabidopsis thaliana. jmj17 loss-of-function mutants displayed dehydration stress tolerance and ABA hypersensitivity in terms of stomatal closure. JMJ17 specifically demethylated H3K4me1/2/3 via conserved iron-binding amino acids in vitro and in vivo. Moreover, H3K4 demethylase activity of JMJ17 was required for dehydration stress response. Systematic combination of genome-wide chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq) and RNA-sequencing (RNA-seq) analyses revealed that a loss-of-function mutation in JMJ17 caused an ectopic increase in genome-wide H3K4me3 levels and activated a plethora of dehydration stress-responsive genes. Importantly, JMJ17 bound directly to the chromatin of OPEN STOMATA 1 (OST1) and demethylated H3K4me3 for the regulation of OST1 mRNA abundance, thereby modulating the dehydration stress response. Our results demonstrate a new function of a histone demethylase under dehydration stress in plants 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Arabidopsis thaliana 
650 4 |a abiotic stress 
650 4 |a abscisic acid (ABA) 
650 4 |a dehydration stress 
650 4 |a histone demethylation 
650 4 |a transcriptional regulation 
650 7 |a Arabidopsis Proteins  |2 NLM 
650 7 |a Chromatin  |2 NLM 
700 1 |a Zhang, Ai  |e verfasserin  |4 aut 
700 1 |a Jin, Jing Bo  |e verfasserin  |4 aut 
700 1 |a Zhao, Bo  |e verfasserin  |4 aut 
700 1 |a Wang, Tian-Jing  |e verfasserin  |4 aut 
700 1 |a Wu, Yifan  |e verfasserin  |4 aut 
700 1 |a Wang, Shuang  |e verfasserin  |4 aut 
700 1 |a Liu, Yutong  |e verfasserin  |4 aut 
700 1 |a Wang, Jie  |e verfasserin  |4 aut 
700 1 |a Guo, Peng  |e verfasserin  |4 aut 
700 1 |a Ahmad, Rafiq  |e verfasserin  |4 aut 
700 1 |a Liu, Bao  |e verfasserin  |4 aut 
700 1 |a Xu, Zheng-Yi  |e verfasserin  |4 aut 
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773 1 8 |g volume:223  |g year:2019  |g number:3  |g day:30  |g month:08  |g pages:1372-1387 
856 4 0 |u http://dx.doi.org/10.1111/nph.15874  |3 Volltext 
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