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231225s2019 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201806656
|2 doi
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|a pubmed24n0988.xml
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|a eng
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|a Mattes, Daniela S
|e verfasserin
|4 aut
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|a Miniaturized and Automated Synthesis of Biomolecules-Overview and Perspectives
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|c 2019
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|a Text
|b txt
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 04.11.2019
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2019 Karlsruhe Institute of Technology, IMT. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Chemical synthesis is performed by reacting different chemical building blocks with defined stoichiometry, while meeting additional conditions, such as temperature and reaction time. Such a procedure is especially suited for automation and miniaturization. Life sciences lead the way to synthesizing millions of different oligonucleotides in extremely miniaturized reaction sites, e.g., pinpointing active genes in whole genomes, while chemistry advances different types of automation. Recent progress in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) imaging could match miniaturized chemical synthesis with a powerful analytical tool to validate the outcome of many different synthesis pathways beyond applications in the life sciences. Thereby, due to the radical miniaturization of chemical synthesis, thousands of molecules can be synthesized. This in turn should allow ambitious research, e.g., finding novel synthesis routes or directly screening for photocatalysts. Herein, different technologies are discussed that might be involved in this endeavor. A special emphasis is given to the obstacles that need to be tackled when depositing tiny amounts of materials to many different extremely miniaturized reaction sites
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|a Journal Article
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|a Review
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|a MALDI-MS imaging
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|a arrays
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|a combinatorial chemistry
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|a flow chemistry
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|a microfluidics
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|a Biocompatible Materials
|2 NLM
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|a Organic Chemicals
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|a Peptides
|2 NLM
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|a Polysaccharides
|2 NLM
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|a Proteins
|2 NLM
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|a Small Molecule Libraries
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|a DNA
|2 NLM
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|a 9007-49-2
|2 NLM
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| 700 |
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|a Jung, Nicole
|e verfasserin
|4 aut
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|a Weber, Laura K
|e verfasserin
|4 aut
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|a Bräse, Stefan
|e verfasserin
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|a Breitling, Frank
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 31(2019), 26 vom: 02. Juni, Seite e1806656
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|x 1521-4095
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|g volume:31
|g year:2019
|g number:26
|g day:02
|g month:06
|g pages:e1806656
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|u http://dx.doi.org/10.1002/adma.201806656
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