|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM296260983 |
| 003 |
DE-627 |
| 005 |
20231225085443.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231225s2019 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2019.04.007
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0987.xml
|
| 035 |
|
|
|a (DE-627)NLM296260983
|
| 035 |
|
|
|a (NLM)31005675
|
| 035 |
|
|
|a (PII)S1521-6616(19)30059-2
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Liu, Shuowu
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Treatment of murine lupus with TIGIT-Ig
|
| 264 |
|
1 |
|c 2019
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 02.04.2020
|
| 500 |
|
|
|a Date Revised 02.04.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2019 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a The TIGIT (T cell immunoreceptor with Ig and ITIM domains) protein is a co-inhibitory receptor that has been reported to suppress autoreactive T and B cells to trigger immunological tolerance. We generated a new recombinant protein by connecting the extracellular domain of murine TIGIT to the Fc region of the mouse immunoglobulin IgG2a. The fusion protein was then characterized. The results suggested that among mice with lupus that were treated with the TIGIT-Ig fusion protein, the onset of proteinuria was delayed, serum concentrations of autoantibodies, such as antinuclear antibodies, were reduced without a decrease in the total IgG concentrations, and the survival rate was significantly increased compared to those of the controls. In conclusion, TIGIT-Ig administration showed promising results for both the prevention and treatment of autoimmune diseases in mice. This indicates that treatment with recombinant human TIGIT-Ig shows promise as an effective way to treat human autoimmune diseases
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Murine lupus
|
| 650 |
|
4 |
|a Targeted therapy
|
| 650 |
|
4 |
|a Tigit
|
| 650 |
|
7 |
|a Antibodies, Antinuclear
|2 NLM
|
| 650 |
|
7 |
|a Immunoglobulin Fc Fragments
|2 NLM
|
| 650 |
|
7 |
|a Immunoglobulin G
|2 NLM
|
| 650 |
|
7 |
|a Receptors, Immunologic
|2 NLM
|
| 650 |
|
7 |
|a Recombinant Fusion Proteins
|2 NLM
|
| 650 |
|
7 |
|a T cell Ig and ITIM domain protein, mouse
|2 NLM
|
| 700 |
1 |
|
|a Sun, Lizhu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Chuqi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Cui, Yingshu
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ling, Yuee
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Tian
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lin, Fangxing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Fu, Wenyan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ding, Min
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Zhang, Shuyi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lei, Changhai
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hu, Shi
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 203(2019) vom: 15. Juni, Seite 72-80
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:203
|g year:2019
|g day:15
|g month:06
|g pages:72-80
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2019.04.007
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 203
|j 2019
|b 15
|c 06
|h 72-80
|