Widespread Striatal Delivery of GDNF from Encapsulated Cells Prevents the Anatomical and Functional Consequences of Excitotoxicity
Methods: Human ARPE-19 cells engineered to secrete high levels of the glial cell line-derived neurotrophic factor (GDNF) were encapsulated into hollow fiber membranes. The devices were implanted into the rat striatum 1 week prior to striatal quinolinic acid injections. Animals were evaluated using a...
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Bibliographische Detailangaben
| Veröffentlicht in: | Neural plasticity. - 1998. - 2019(2019) vom: 31., Seite 6286197
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| 1. Verfasser: |
Emerich, Dwaine F
(VerfasserIn) |
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| Weitere Verfasser: |
Kordower, Jeffrey H,
Chu, Yaping,
Thanos, Chris,
Bintz, Briannan,
Paolone, Giovanna,
Wahlberg, Lars U |
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| Format: | Online-Aufsatz
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| Sprache: | English |
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| Veröffentlicht: |
2019
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| Zugriff auf das übergeordnete Werk: | Neural plasticity
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| Schlagworte: | Journal Article
Glial Cell Line-Derived Neurotrophic Factor
Neuroprotective Agents
Quinolinic Acid
F6F0HK1URN |
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